introduction: giant cell lesions of the bone comprise a group of jaw bone pathologies. different pathogeneses such as reactive, vascular or neoplastic have been proposed for these lesions. in addition, differentiating between aggressive and nonaggressive central giant cell granuloma (cgcg) of the jaws based on histopathologic features is still impossible and due to different treatment protocols...

objective: a number of studies have demonstrated the potential antitumor effects of saffron and its constituents on different malignant cells in vitro. it has been reported that a novel glycoconjugate isolated from corms and callus of saffron possesses cytotoxic activity against different tumor cellswith nitric oxide (no) production. these data suggest that the cytotoxic effect of saffron extra...

a primary intraosseous carcinoma (pioc) is a squamous cell carcinoma arising within the  jawbone andshould be differentiated from a malignant ameloblastoma.  it  is not due to arising from an odontogenic cyst or tumor. the possibility of the lesion being  a metastasis fromanotherprimary site should be considered, and excluded by a careful history and examination. the diagnosis of a pioc is rare...

Clear cell chondrosarcoma may be difficult to distinguish from metastatic clear cell renal carcinoma. Clear cell chondrosarcoma is strongly positive for 5100 and negative for epithelial markers. Clear cell carcinoma is cytokeratin positive and may also be positive with SiQO. S100 may also be useful in confirming grade 3 chondrosarcoma and mesenchymal chondrosarcoma. SiQO may assist in distingui...

Basal cell carcinoma (BCC) is the most common cutaneous malignancy. Giant BCCs are quite rare. They can cause extensive local invasion, disfigurement, and metastasis. We present a case of a 58-year-old woman with an unrecognized and inadequately treated ulcerated giant BCC sized 12.5 × 10.0 cm that occurred on her left lower leg without any sign of metastasis. Neglect and inadequate treatment o...

We thank Mengoli and colleagues for their interest in our article (1) and their comprehensive review of METD14-positive pulmonary sarcomatoid carcinomas (PSC) been reported in the literature. We agree with their observation that METD14 seems to be associated with the presence of adenocarcinoma component. Of the 7 METD14-positive PSCs in our series, 5 contain adenocarcinoma components admixed wi...

  Ependymomas accounts for about 2%–6% of CNS and 60%–70% of spinal cord tumors. Several histological patterns of these neoplasms are well known, but little attention has been devoted to a variant composed of giant cells. In spite of apparently “worrisome” histology, giant cell ependymoma seems to be a neoplasm with a relatively good prognosis. This report presents a case of giant cell ependym...

CT: computed tomography cSCC: cutaneous squamous cell carcinoma NMSC: nonmelanoma skin cancer INTRODUCTION Cutaneous squamous cell carcinoma (cSCC), a subset of nonmelanoma skin cancer (NMSC), is a common form of skin malignancy. National cancer registries have traditionally not tracked cSCC, but its 2012 incidence within the US white population was estimated to be within 186,157 and 419,543. N...

abstract carcinoma of the vulva has commonly been recognized as a disease of postmenopausal women, but some cases have been reported in young women during pregnancy. medical records were reviewed for a patient with vulvar carcinoma diagnosed in pregnancy. using medline and cross references, pertinent articles were sought and reviewed. a 28-year-old afghan woman in her sixth pregnancy presented ...