BACKGROUND The aim of this study was to investigate the relationship between congenital hypothyroidism and several variables using two different adjustment methods. METHODS This matched case-control study was conducted in Hamadan Province, the west of Iran, in 2012 enrolling neonates born between 2005 and 2011 and covered by screening program for congenital hypothyroidism. The neonates with T...

Congenital hypothyroidism (CH) is one of the most common endocrine disorders in the infant population. It is also one of the most important causes of foreseeable brain damage and severe mental impairment. Current views on CH pathogenesis, screening schema and treatment standards have been presented. Also outlined have been the newest reports on the impact on CH epidemiology and classification g...

Developmental exposure to polychlorinated biphenyls (PCBs) is associated with a variety of cognitive deficits in humans, and recent evidence implicates white matter development as a potential target of PCBs. Because PCBs are suspected of interfering with thyroid hormone (TH) signaling in the developing brain, and because TH is important in oligodendrocyte development, we tested the hypothesis t...

Introduction: Autoimmune thyroid diseases are common findings in women of childbearing age that could affect fertility rate, pregnancy outcome and complications after pregnancy. These also correlated with other autoimmune diseases. Objectives: In this study, we aim to evaluate the disease aged 35 45 years based on Azar cohort study data. Patients Methods: cross-sectional analytical 507 35-45 ol...

Neonatal haemochromatosis is a rare alloimmune gestational disease with a high mortality. The hallmark of neonatal haemochromatosis is severe neonatal liver failure associated with extrahepatic siderosis. Thus far, no pituitary dysfunction has been reported to result from the tissue damage associated with extrahepatic siderosis. The present report describes a neonate with neonatal haemochromato...

Background: The gram-positive, beta-hemolytic, and chain-forming Group B Streptococcus (GBS), commonly known as agalactiae, may asymptomatically invade the human gastrointestinal vaginal tracts. However, GBS become very invasive pathogenic to mother baby during pregnancy, having negative effects. Study Aim: This study aims investigate pregnancy outcomes of women who tested positive for genitour...

Objective: To determine the frequency of congenital hypothyroidism (CH) in healthy newborns. Study Design: Cross-sectional study. Setting: Department Neonatology, Children Hospital & Institute Child Health Multan. Period: July 2020 to January 2021. Material Methods: Neonates both genders between 48 hours life 28 days age delivered after 37-weeks gestation were analyzed. All neonates underwe...

Thyroid hormones regulate adult metabolism partly through actions on mitochondrial oxidative phosphorylation (OXPHOS). They also affect neurological development of the brain, but their role in cerebral OXPHOS before birth remains largely unknown, despite increase energy demand during neonatal period. Thus, this study examined prepartum hypothyroid fetal sheep. Using respirometry, Complex I (CI)...

This study explored the effects of levothyroxine (L-T4) replacement therapy on pregnancy outcomes in patients with subclinical hypothyroidism (SCH). We analyzed the effects on pregnancy outcomes with respect to gestational week when the desired thyroid-stimulating hormone (TSH) level was reached as well as the length of time required to reach the target level during L-T4 treatment. This study e...