Background: Development of relative insulin resistance during pregnancy is a normal physiologic change related to placental lactogen and pregnancy-associated elevated lipid concentrations. Several studies have investigated the role of tissue response, tyrosine kinase insulin receptor phosphorylation, and other cytokines that might contribute to development of such resistance. In this study, we ...

Background: Gestational diabetes (GA) is a common complication, associated with adverse prenatal outcomes and perceived stress. The effects of education on perceived stress have been widely investigated, whereas the role of self-care in GA has been less noted. Aim: to determine the effects of self-care education on perceived stress in women with GA under insulin treatment. Methods: In this rand...

OBJECTIVE The aim of this meta-analysis was to determine the efficacy and safety of glyburide as a treatment for gestational diabetes mellitus (GDM) compared to insulin. METHODS A meta-analysis was conducted to compare the management of gestational diabetes with glyburide and insulin. Studies fulfilling all of the following inclusion criteria were included in this meta-analysis: subjects were...

Objective: A2 gestational diabetes mellitus (A2GDM) is a more severe form of GDM that requires additional medical intervention, such as insulin or oral antidiabetic drug (OAD). The present study explored the determinants A2GDM and analyzed associated risk post-partum prediabetes.
 Methods: This retrospective included 247 pregnant women, diagnosed with followed up until delivery at Obstetri...

Placental damage may be responsible for the fetal complications in pregnancies complicated by diabetes. We have analyzed the prevalence of gestational diabetes (GD) in a population of 109 pregnant women, the risk factors and the placental changes associated with gestational diabetes. Tests carried out were oral glucose tolerance test at 24-28 weeks of gestation, using the IADPSG (International ...

Diabetes mellitus comprises a heterogeneous group of disorders characterized by high blood glucose levels. Four major types of diabetes have been defined by the National Diabetes Data Group (NDDG) and the World Health Organization (WHO): insulin-dependent diabetes mellitus (IDDM), non-insulin-dependent diabetes mellitus (NIDDM), gestational diabetes mellitus (GDM), and diabetes secondary to oth...

Objective: To study the efficacy and safety of glibenclamide/metformin combination as a treatment option for pregnant women with either gestational diabetes or type-2 diabetes mellitus compared to conventional insulin therapy. Methods: Eighty-four pregnant women with singleton pregnancies (65 women with gestational diabetes & 19 with type-2 diabetes mellitus) were included. They were randomly a...

Gestational diabetes mellitus (GDM) shows a deficiency in the metabolism of D-glucose and other nutrients, thereby negatively affecting foetoplacental vascular endothelium. Maternal hyperglycaemia hyperinsulinemia play an important role aetiology GDM. A combination these factors predisposes women to developing GDM with pre-pregnancy normal weight, viz. classic However, prepregnancy obesity (ges...

Pregnancy affects both maternal and fetal metabolism, and even in non-diabetic women, it exerts a diabetogenic effect. Among pregnant women, 2% to 14% develop gestational diabetes. Pregnancy can also occur in women with preexisting diabetes, which may predispose the fetus to many alterations in organogenesis, restrict growth, and the mother, to some diabetes-related complications, such as retin...