In this study, we have examined the potential of second-generation antisense chimeric 2'-O-(2-methoxy)ethyl/DNA phosphorothioate oligonucleotides (ONs) to affect cell growth through non-antisense mechanisms. Evaluation of a series of ONs demonstrated that only a small number were cytotoxic at concentrations close to those required for antisense activity. Toxicity of the ONs appeared to be seque...

Automatic generation of test cases for functional testing is a challenging task. It involves complex sub tasks such as capturing user scenarios, parsing user scenarios to generate test cases, ensuring test coverage criteria, test script generation from test cases, test execution and report generation. In this paper, a method is proposed to generate test cases after parsing Sequence diagram and ...

Test generation at the gate-level produces high-quality tests but is computationally expensive in the case of large systems. Recently, several research efforts have investigated the possibility of devising test generation methods and tools to work on high-level descriptions. The goal of these methods is to provide the designers with testability information and test sequences in the early design...

An Event Sequence Graph (ESG) is a simple albeit powerful formalism for capturing the behavior of a variety of interactive systems that include real-time, embedded systems, and graphical user interfaces. A collection of ESGs is proposed as a model of an interactive system. This collection is used for the generation of tests to check for the correctness of system behavior in the presence of expe...

Software testing is an important but complex part of software development life cycle. The optimization of the software testing process is a major challenge, and the generation of the independent test paths remains unsatisfactory. In this paper, we present an approach based on metaheuristic firefly algorithm to generate optimal test paths. In order to optimize the test case paths, we use a modif...

In power estimation, one is faced with two problems: 1) generating input vector sequences that satisfy a given statistical behavior (in terms of signal probabilities and correlations among bits); 2) making these sequences as short as possible so as to improve the efficiency of power simulators. Stochastic sequential machines (SSMs) can be used to solve both problems. In particular, this paper p...

Markov processes are widely used to generate sequences that imitate a given style, using random walk. Random walk generates sequences by iteratively concatenating states to prefixes of length equal or less than the given Markov order. However, at higher orders, Markov chains tend to replicate chunks of the corpus with a size possibly higher than the order, a primary form of plagiarism. The Mark...

SUMMARY Tablet is a lightweight, high-performance graphical viewer for next-generation sequence assemblies and alignments. Supporting a range of input assembly formats, Tablet provides high-quality visualizations showing data in packed or stacked views, allowing instant access and navigation to any region of interest, and whole contig overviews and data summaries. Tablet is both multi-core awar...

This paper considers the test case generation for distributed software (a test case contains one or more test sequences). Applying the single finite state machine (FSM) test approach to distributed software, we will suffer from some problems: 1) the state combinatorial explosion problem; 2) some unexecutable test cases may be generated; 3) some fault may be masked and cannot be isolated accurat...

The recent research results from the Protocol Engineering Lab of the University of Delaware in minimum-length test generation based on Estelle speci cations are summarized. The methods use models restricting the number of self-loops to be consecutively traversed for each state, and utilizing semicontrollable interfaces of the IUT to increase the number of testable transitions. The initial resul...