"Dravet syndrome" (DS) previously named severe myoclonic epilepsy of infancy (SMEI), or epilepsy with polymorphic seizures, is a rare disorder characterized by an early, severe, generalized, epileptic encephalopathy.DS is characterized by febrile and afebrile seizures beginning in the 1st year of life followed by different types of seizures (either focal or generalized), which are typically res...

conclusions it became clear at the end of the study that the effectiveness of two drugs were the same and they didn’t have any meaningful difference. according to the result gained from this study, levetiracetam is a proper alternative treatment instead of sodium valproate which has appropriate effectiveness along with lower complications. results comparison of mean generalized tonic colonic at...

OBJECTIVE To investigate the demographic and clinical characteristics of epilepsy in 2 referral hospitals in northern Iran. METHODS In this cross-sectional study, we evaluated 300 patients with the confirmed diagnosis of epilepsy referred to the Neurology clinics of 22-Bahman, and 17-Shahrivar Hospitals, Mashad, Iran, from April 2011 to December 2012. We collected and analyzed demographic and...

background: imaging studies performed in research centers suggest a high prevalence of brain structural abnormalities in patients with epilepsy. however, the results of research studies may not be directly applicable to general clinic, because they may perform on patients with high probability of cerebral abnormalities. on the other hand, more advanced modalities are likely to be used in resear...

Doose syndrome, otherwise traditionally known as myoclonic-astatic epilepsy, was first described as a unique epilepsy syndrome by Dr Hermann Doose in 1970. In 1989, the International League Against Epilepsy classified it formally as a symptomatic generalized epilepsy, and 20 years later it was renamed 'epilepsy with myoclonic-atonic seizures'. In this review, we discuss the components of this u...

In a given population, certain individuals are much more likely to have seizures than others. This increase in seizure susceptibility can lead to spontaneous seizures, such as seen in idiopathic epilepsy, or to symptomatic seizures that occur after insults to the nervous system. Despite the frequency of these seizure disorders in the human population, the genetic and physiological basis for the...

We reviewed 18 EEG studies in four members of a family with the Lafora form of progressive myoclonic epilepsy. Each patient was the product of a consanguinous marriage and presented as a teenager with progressive seizures, myoclonus, dementia, and ataxia, and had biopsy proven disease. The EEG early in Lafora disease has spike-wave activity resembling that seen in a primary generalized epilepsy...

OBJECTIVES Using an adult cohort of patients with generalized epilepsy, we aimed to identify risk factors for development of drug-resistant epilepsy (DRE), which if identifiable would allow patients to receive earlier treatment and more specifically individualized treatment plans. METHODS For the case-control study, 118 patients with generalized epilepsy (GE) between the ages of 18 and 75 wer...

www.aafp.org/afp AMERICAN FAMILY PHYSICIAN 91 tion or video review because the diagnosis requires other information, such as age of onset, etiology, family history, seizure frequency, imaging studies, precipitating factors, electroencephalography (EEG) and natural history. Most types of epilepsy are characterized by more than one type of seizure. Patients with focal (or partial) epilepsy may ha...

OBJECTIVE We studied the frequency of auras in generalized epilepsy (GE) using a detailed semistructured diagnostic interview. METHODS In this cross-sectional study, participants with GE were drawn from the Epilepsy Phenome/Genome Project (EPGP). Responses to the standardized diagnostic interview regarding tonic-clonic (grand mal) seizures were then examined. This questionnaire initially requ...