background : interleukin (il)-4 is a member of t helper 2 (th2) axis produced by t-lymphocyte and mast cell. it has been shown that il-4 expression changes in tumor tissues. the main objective of this study is to investigate the expression of il-4 mrna in patients with laryngeal squamous cell carcinoma (lscc) with or without lymph node involvement. materials and methods: mrna expression of il-4...

Purpose: to evaluate the effect of primary open-angle glaucoma (POAG) as a comorbidity on cytokine expression in aqueous humor (AqH) patients with Fuchs endothelial corneal dystrophy (FECD) and bullous keratopathy (BK). Patients methods. In this prospective consecutive case study 58 (58 eyes) were divided into 2 main groups. Group 1 (22 FECD) included 11 coexisting POAG II–IIIA (group 1a) witho...

Background : Allergic asthma is a chronic inflammatory disease of airway that often determined with degrees of inflammation, hypersensitivity, bronchial constriction and airway changes. Th1, Th2 and Th17 cells are the main cells involved in the pathophysiology of asthma. . Therefore, this study evaluated Th1, Th2, and Th17 cells functions by assessment the expression of INF-g, IL-4, and IL-17 g...

Abstract In normal wound healing, macrophages regulate early and late inflammation, allowing for resolution of tissue injury subsequent healing. During repair, undergo transition to myofibroblasts, which promote While this critical is impaired in diabetic wounds, the underlying mechanisms responsible are unknown. Our group others have identified that epigenetic regulation controls their phenoty...

Acute pancreatitis (AP) has a fast onset and progression, which lead to an unfavorable prognosis. Therefore, the development of novel drugs for its treatment is critical. As a homologous derivative of resveratrol, pterostilbene exerts a variety of effects including anti-inflammatory, antioxidant, and antitumor effects. This study investigated the potential of pterostilbene for treatment of seve...

OBJECTIVES The aim of this study is to clarify the associations between IL-1B31C/T, IL-1B-511C/T, IL-8-251T/A gene polymorphisms and the risk of Helicobacter pylori (H. pylori) infection together with H. pylori-related gastric cancer (GC), peptic ulcer disease (PUD). METHODS All eligible literature published up to July 2016 were identified by searching Pubmed, Embase, Web of Science and CNKI....

Teng, Xingwu, Hanfang Zhang, Connie Snead, and John D. Catravas. Molecular mechanisms of iNOS induction by IL-1b and IFN-g in rat aortic smooth muscle cells. Am J Physiol Cell Physiol 282: C144–C152, 2002;—In rat aortic smooth muscle cells (RASMC), interferon (IFN)-g enhanced nitrite accumulation and type II nitric oxide synthase (iNOS) protein expression induced by interleukin (IL)-1b. IFN-g a...