It had became a challenging experience and effort for formulator to develop innovate drug with maximum bioavailability. In the present study focus of research is in treatment Hypertension, which one most prevalent cardiovascular diseases world, affecting big proportion adult old age population. Candesartan Cilexetil angiotensin II AT1 many tissues including vascular smooth muscle adrenal glands...

OBJECTIVES The diagnosis of lung cancer remains a clinical challenge. Many studies have assessed the diagnostic potential of anti-p53 antibody in lung cancer patients but with controversial results. This study aims to summarize the overall diagnostic performance of anti-p53 antibody in lung cancer. MATERIALS AND METHODS Based on a comprehensive search of the Pubmed and Embase, we identified o...

Objective To compare cancer screening and flu vaccination among persons with and without unhealthy substance use. Design The authors analysed data from 4804 women eligible for mammograms, 4414 eligible for Papanicolou (Pap) smears, 7008 persons eligible for colorectal cancer (CRC) screening and 7017 persons eligible for flu vaccination. All patients were screened for unhealthy substance use. T...

CO and H I velocity fields of seven nearby spiral galaxies, derived from radio-interferometric observations, are decomposed into Fourier components whose radial variation is used to search for evidence of radial gas flows. Additional information provided by optical or near-infrared isophotes is also considered, including the relationship between the morphological and kinematic position angles. ...

The strong intervening absorption system at redshift 1.15 towards the very bright quasar HE 0515?4414 is most studied absorber for measuring possible cosmological variations in fine-structure constant, ? . We observed 16.1 h with Very Large Telescope and present here first constraint on relative parts-per-million (ppm) precision from new ESPRESSO spectrograph: ? / = 1.3 ± stat 0.4 sys ppm. stat...

PTPN11, which encodes the tyrosine phosphatase SHP2, is mutated in approximately 35% of patients with juvenile myelomonocytic leukemia (JMML) and at a lower incidence in other neoplasms. To model JMML pathogenesis, we generated knockin mice that conditionally express the leukemia-associated mutant Ptpn11D61Y. Expression of Ptpn11D61Y in all hematopoietic cells evokes a fatal myeloproliferative ...

Many-multiplet (MM) method [1] applied to Keck/HIRES quasar absorption spectra gives a shift in the value of the fine-structure constant of ∆α/α = (−5.4±1.2)×10−6 [2]. Theoretical models of the fundamental physical interactions predict in this case a shift in the protonto-electron mass ratio (μ = mp/me) of about ∆μ/μ ∼ −2× 10−4. We used VLT/UVES high-resolution observations of molecular hydroge...

Sterol regulatory element-binding proteins (SREBPs) are major transcriptional regulators of cholesterol, fatty acid, and glucose metabolism. Genetic disruption of SREBP activity reduces plasma and liver levels of cholesterol and triglycerides and insulin-stimulated lipogenesis, suggesting that SREBP is a viable target for pharmacological intervention. The proprotein convertase SREBP site 1 prot...

In this study, a gelatin microparticle-containing self-microemulsifying formulation (SMF) was developed using a spray-drying method to enhance the oral delivery of the poorly water-soluble therapeutic dutasteride. The effect of the amount of gelatin and the type and amount of hydrophilic additives, namely, Gelucire(®) 44/14, poloxamer 407, sodium lauryl sulfate, Soluplus(®), Solutol™ HS15, and ...