BACKGROUND The intention of this research was to prepare and compare various solubility-enhancing nanoparticulated systems in order to select a nanoparticulated formulation with the most improved oral bioavailability of poorly water-soluble fenofibrate. METHODS The most appropriate excipients for different nanoparticulated preparations were selected by determining the drug solubility in 1% (w...

The aim of the current study was to develop a nanostructured double-layer for hydrophobic molecules delivery system. developed consisted polyethylene glycol-based polymeric (PEG) followed by gelatin sub coating core containing sodium citrate. composition ratio PEG and amount were optimized using two-level fractional method. nanoparticles characterized AFM FT-IR techniques. size these nano capsu...

Silver nanoparticles are produced using various physical, chemical or physicochemical methods. Simple low-cost nontoxic environmentally friendly, “green”, chemistry methods important, especially for their invasive application in the medicine and food industries. Silver-nanoparticle-enriched biocompatible films were at room temperature from fresh beetroot juice, AgNO3 gelatin–water solution phot...

Phospholipids are category of nutrients that essential for growth and health maintenance. They commonly supplied from animal-derived foods. However, plant-derived phospholipids like soy lecithin seems also to be potential alternative because they well received by different population who have concerns about The purpose the current investigation is formulate gelatin-based matrix bearing as a mod...

BACKGROUND Development of an effective non-viral vaccine against hepatitis C virus infection is of a great importance. Gelatin nanoparticles (Gel.NPs) have an attention and promising approach as a viable carrier for delivery of vaccine, gene, drug and other biomolecules in the body. AIM OF WORK The present study aimed to develop stable Gel.NPs conjugated with nonstructural protein 2 (NS2) gen...

PURPOSE Intranasal administration of phospholipid-based gelatin nanoparticles (GNP) was prepared to investigate the neuro-recovery effects of neuropeptide Substance P (SP) on hemiparkinsonian rats. METHODS The SP-loaded gelatin nanoparticles (SP-GNP) were prepared by a water-in-water emulsion method and possessed high stability, encapsulating efficiency and loading capacity. PC-12 cells were ...

Introduction. Trypsin (EC 3.4.21.4) is a protein degrading enzyme of the group of the serine proteases having many applications: in food and beverage industries for protein hydrolysates production, in cold stabilization of beer etc. It is employed in biochemistry for protein identification through peptide sequencing techniques [1]. The activity of trypsin serves as a reliable diagnostic test of...

Viral nucleic acids are recognized by specific pattern-recognition receptors of the Toll-like and RIG-I-like receptor families. Synthetic DNA and RNA oligonucleotides can activate the immune system through these receptors and potentiate Ab and CD8 cytotoxic responses to Ags. Systemic application of immunostimulatory oligonucleotides however also results in a generalized, non-Ag-specific stimula...

In the current work, a new antibacterial bandage was proposed where diamond-like carbon with silver nanoparticle (DLC:Ag)-coated synthetic silk tissue was used as a building block. The DLC:Ag structure, the dimensions of nanoparticles, the silver concentration and the silver ion release were studied systematically employing scanning electron microscopy, energy dispersive X-ray spectroscopy and ...

In this study, it is aimed to produce composite hydroxyapatite (HA) gelatin microspheres (HA-Gel) intended for drug delivery applications. The polymer network within the HA particle-matrix can be facilitated as a carrier system. dissolution of in physiological medium allows release controlled manner and also develop cell-microsphere interactions. Gelatin functionalized bare granules were produc...