PURPOSE To develop an in situ gel system comprising liposome-containing paclitaxel (PTX) dispersed within the thermoreversible gel (Pluronic® F127 gel) for controlled release and improved antitumor drug efficiency. METHODS The dialysis membrane and membrane-less diffusion method were used to investigate the in vitro drug release behavior. Differential scanning calorimetry (DSC) thermal analys...

introduction: alveolar osteitis (ao) is one of the most common postoperative complications after third molar surgery. various techniques have been used to reduce the risk of ao. the aim of the current study was to evaluate the effect of chlorhexidine (chx) bioadhesive gel in preventing the development of ao. methods: patients with bilateral impacted mandibular third molars underwent surgical ex...

Freeze-dried juice obtained from Aloe vera and heated for 15 minutes at 80 degrees inhibited several test microorganisms. Species of Aloe have had a long history as drug plants. This was pointed out by Morton (1) in a recent comprehensive review of Aloe from the standpoint of folk use and commercial exploitation. Fly and Kiem (2) recently carried out an investigation to ascertain whether Aloe v...

Conflicting experimental results have been reported for the plateau modulus in actin solutions: Analogies are often made with the viscoelastic behaviour of flexible polymers making use of the idea of entanglement as the source of the macroscopic storage modulus. We resolve apparent experimental and theoretical contradictions by pointing out the possibility of two distinct plateau regimes as a f...

We report a piezoelectric effect in cholesteric liquid crystalline elastomer gels. When we apply a shear stress to a cholesteric elastomer gel in the direction perpendicular to its helical axis, a polarization can be induced in the direction perpendicular to both the stress and the helix. This experimental observation agrees with the theory proposed by Pelcovits and Meyer ͓J.

The Hall resistance was measured by the van der Pauw method on Y Ba2Cu3Ox samples in magnetic fields up to 5 T. In region from 0 to 0.2 T the part of the resistance due to transversal electric field, which is even in magnetic field has been observed just below the critical temperature. This part is gradually suppressed in higher field. Only the Hall resistance (due to odd transversal voltage) h...

Oxybutynin is an efficacious treatment for overactive bladder, but its clinical utility is hampered by relative intolerability due to its side effect profile. Over the last few years, various attempts to enhance the tolerability of oxybutynin by varying the drug delivery mechanism have been introduced and have included extended release, rectal suppository, transdermal patch, and gel formulation...