نتایج جستجو برای: gdnf glial cell line derived neurotrophic factor

تعداد نتایج: 2896966  

2013
Martina Böttner Martina Barrenschee Ines Hellwig Jonas Harde Jan-Hendrik Egberts Thomas Becker Dimitri Zorenkov Karl-Herbert Schäfer Thilo Wedel

BACKGROUND & AIMS Absence of glial cell line-derived neurotrophic factor (GDNF) leads to intestinal aganglionosis. We recently demonstrated that patients with diverticular disease (DD) exhibit hypoganglionosis suggesting neurotrophic factor deprivation. Thus, we screened mRNA expression pattern of the GDNF system in DD and examined the effects of GDNF on cultured enteric neurons. METHODS Colo...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2001
S Linnarsson A Mikaels C Baudet P Ernfors

Glial cell line-derived neurotrophic factor (GDNF) promotes the survival of postnatal-but not embryonic-mouse dorsal root ganglion cells in vitro, despite the fact that its receptors are expressed at both ages. To understand this difference, we have performed an oligonucleotide microarray experiment. We found that several hundred genes were regulated between embryonic and postnatal stages, and ...

Journal: :Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 2011
D M Rodrigues A Y Li D G Nair M G Blennerhassett

BACKGROUND The enteric nervous system (ENS) continues its structural and functional growth after birth, with formation of ganglia and the innervation of growing smooth muscle. However, little is known about factors in the postnatal intestine that influence these processes. METHODS We examined the presence and potential role of glial cell line-derived nerve growth factor (GDNF) in the rat post...

Journal: :Brain : a journal of neurology 2011
Mickael Decressac Ayse Ulusoy Bengt Mattsson Biljana Georgievska Marina Romero-Ramos Deniz Kirik Anders Björklund

The neuroprotective effect of the glial cell line-derived neurotrophic factor has been extensively studied in various toxic models of Parkinson's disease. However, it remains unclear whether this neurotrophic factor can protect against the toxicity induced by the aggregation-prone protein α-synuclein. Targeted overexpression of human wild-type α-synuclein in the nigrostriatal system, using aden...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 1998
V Arce R A Pollock J M Philippe D Pennica C E Henderson O deLapeyrière

The survival of central neurons depends on multiple neurotrophic factors produced by different cell types. We demonstrate that media conditioned by muscle and Schwann cell lines show strong synergistic effects on survival of purified embryonic day 14.5 rat motoneurons in culture. Different lines of evidence implicate glial cell line-derived neurotrophic factor (GDNF) and cardiotrophin-1 (CT-1) ...

2003
ILLANA GOZES Penka S. Petrova Andrei Raibekas Jonathan Pevsner Noel Vigo Mordechai Anafi Mary K. Moore Amy E. Peaire Viji Shridhar David I. Smith John Kelly Yves Durocher John W. Commissiong

We describe the discovery of a novel, 20 kDa, secreted human protein named mesencephalic astrocyte-derived neurotrophic factor, or MANF. The homologous, native molecule was initially derived from a rat mesencephalic type-1 astrocyte cell line and recombinant MANF subcloned from a cDNA encoding human arginine-rich protein. MANF selectively protects nigral dopaminergic neurons, versus GABAergic o...

Journal: :Trends in pharmacological sciences 2006
Ora Schueler-Furman Eitan Glick José Segovia Michal Linial

Glial-cell-line-derived neurotrophic factor (GDNF) is a survival and maintenance factor for dopamine-containing neurons and motoneurons. GDNF belongs to a family of structurally related factors that includes neurturin (NRTN), artemin (ARTN) and persephin (PSPN). An initial step in the activation of signaling via the GDNF family of ligands (GFLs) is their binding to their cognate co-receptor GFR...

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