Corticosterone, the major stress hormone, plays an important role in regulating neuronal functions of the limbic system, though the cellular targets and molecular mechanisms of corticosteroid signaling are largely unknown. Here we show that a short treatment of corticosterone significantly increases AMPARmediated synaptic transmission and AMPAR membrane trafficking in pyramidal neurons of prefr...

Protein synthesis factor eIF2 delivers initiator tRNA to the ribosome. Two proteins regulate its G-protein cycle: eIF5 has both GTPase-accelerating protein (GAP) and GDP dissociation inhibitor (GDI) functions, and eIF2B is the guanine nucleotide exchange factor (GEF). In this study, we used protein-protein interaction and nucleotide exchange assays to monitor the kinetics of eIF2 release from t...

Prenylated Rab GTPases regulate intracellular vesicle trafficking in eukaryotic cells by associating with specific membranes and recruiting a multitude of Rab-specific effector proteins. Prenylation, membrane delivery, and recycling of all 60 members of the Rab GTPase family are regulated by two related molecules, Rab escort protein (REP) and GDP dissociation inhibitor (GDI). Biophysical analys...

The United States has two measures of economic output: gross domestic product (GDP) and income (GDI). While these are conceptually equivalent, their initial estimates differ because computed from different incomplete data sources. I study the difference, or “statistical discrepancy,” between GDP GDI in percent document three features. First, its size does not materially shrink on average as mor...

This paper presents logic style comparisons based on different logic functions and claimed modified Gate Diffusion Input logic (Mod-GDI) to be much more power-efficient than Gate Diffusion Input logic (GDI) and complementary CMOS logic design. However, DC and Transient analysis performed on more efficient modified Gate Diffusion Input logic (Mod-GDI) circuit realizations and a wider range of di...

We estimate a predictive single factor model targeted to unobserved common growth in gross domestic product and income (GDI) using state-space framework with select state employment data. use likelihood-based comparison the states dynamic factor. The results show improved in-sample out-of-sample performance than threshold principal component factors financial spreads. Out-of-sample evaluations ...

Gestational diabetes insipidus (GDI) refers to the state of excessive water intake and hypotonic polyuria. Those cases manifesting in pregnancy and referred to as GDI may persist thereafter or may be a transient latent form that resolves after delivery. Microscopic examination of affected subjects has not been previously reported. In the literature, there are various case reports and case serie...

in this work, result of experimental investigation on interaction of fuel spray generated by a swirled type injector, with air motion in a prototype cylinder are presented. experiments were carried out by planar imaging and particle image velocimetry (piv) techniques in order to provide information about the spray structure evolution and instantaneous velocity distribution of air motion and fue...