Gross chromosomal rearrangements (GCRs) play an important role in human diseases, including cancer. The identity of all Genome Instability Suppressing (GIS) genes is not currently known. Here multiple Saccharomyces cerevisiae GCR assays and query mutations were crossed into arrays of mutants to identify progeny with increased GCR rates. One hundred eighty two GIS genes were identified that supp...

An understanding of how the heliosphere modulates galactic cosmic ray (GCR) fluxes and spectra is important, not only for studies of their origin, acceleration and propagation in our galaxy, but also for predicting their effects (on technology and on the Earth’s environment and organisms) and for interpreting abundances of cosmogenic isotopes in meteorites and terrestrial reservoirs. In contras...

Identifying the different varieties of the same language is more challenging than unrelated languages identification. In this paper, we propose an approach to discriminate language varieties or dialects of Mandarin Chinese for the Mainland China, Hong Kong, Taiwan, Macao, Malaysia and Singapore, a.k.a., the Greater China Region (GCR). When applied to the dialects identification of the GCR, we f...

This paper discusses performance optimization on the dynamical core of global numerical weather prediction model in Global/Regional Assimilation and Prediction System (GRAPES). GRAPES is a new generation of numerical weather prediction system developed and currently used by Chinese Meteorology Administration. The computational performance of the dynamical core in GRAPES relies on the efficient ...

Astronauts on a mission to Mars would be exposed for up to 3 years to galactic cosmic rays (GCR)--made up of high-energy protons and high charge (Z) and energy (E) (HZE) nuclei. GCR exposure rate increases about three times as spacecraft venture out of Earth orbit into deep space where protection of the Earth's magnetosphere and solid body are lost. NASA's radiation standard limits astronaut ex...

Toluene is an important toxic volatile agent found in many modern industrial processes. Toluene exposure is of particular concern because of the ongoing exposure of thousands of workers in industrial plants and recent research has indicated that toluene/exposure can result in chronic toxicity. The monitoring and control of toluene exposure among at-risk workers is necessary. Urine hippuric acid...

BACKGROUND Urine albumin excretion is an important predictor of adverse cardiovascular events in various populations. Its correlation in patients with acute heart failure has not been described. METHODS AND RESULTS This prospective, observational study included 115 patients presenting with acute heart failure. The urine albumin/creatinine ratio (UACR) was measured from spot urine samples coll...

Clinical treatment with glucocorticoids (GC) can be complicated by cytokine-induced glucocorticoid low-responsiveness (GC-resistance, GCR), a condition associated with a homogeneous reduction in the expression of GC-receptor- (GR-) driven anti-inflammatory genes. However, GR level and phosphorylation changes modify the expression of individual GR-responsive genes differently. As sustained IL-1β...

Mutants have been isolated in S. cerevisiae with the phenotype of growth on pyruvate but not on glucose, or growth on rich medium with pyruvate but inhibition by glucose. Screening of mutagenized cultures was either without an enrichment step, or after enrichment using the antibiotic netropsin (Young et al. 1976) or inositol starvation (Henry, Donahue and Culbertson 1975). One class of mutants ...

Galactic cosmic ray (GCR) measurements of the phosphorus, sulfur, argon, and calcium isotopes made by the Cosmic Ray Isotope Spectrometer (CRIS) aboard NASA’s Advanced Composition Explorer are reported over the energy range from ∼100 to ∼400 MeV/nucleon. The propagation of cosmic rays through the Galaxy and heliosphere is modeled to determine isotopic source abundance ratios P/S , S/S , Ar/Ar ,...