DNA adenine methyltransferase (Dam) not only regulates basic cellular functions but also interferes with the proper expression of virulence factors in various pathogens. We showed previously that for the human pathogen Yersinia enterocolitica, overproduction of Dam results in increased invasion of epithelial cells. Since invasion and motility are coordinately regulated in Y. enterocolitica, we ...

Pasteurella multocida is one of the primary bacterial pathogens associated with bovine respiratory disease (BRD) complex. Relatively few virulence factors of P. multocida have been characterized, and there is a need for improved vaccines for prevention of BRD. In other Gram-negative species, DNA adenine methylase (Dam) regulates the expression of virulence genes, and appropriate expression of D...

Dam removal is an increasingly popular restoration tool, but our understanding of ecological responses to dam removal over time is still in the early stages. We quantified seasonal benthic macroinvertebrate density, taxonomic composition, and functional traits for three years after lowhead dam removal in three reaches of the Olentangy River (Ohio, USA): two upstream of former dam (one restored,...

BACKGROUND Rotavirus infection is responsible for about 500,000 deaths annually, and the disease burden is disproportionately borne by children in low-income countries. Recently the World Health Organization (WHO) has released a global recommendation that all countries include infant rotavirus vaccination in their national immunization programs. Our objective was to provide information on the e...

Luis Sambo, Margaret Chan, Steve Davis, Anthony Lake, Seth Berkley, Cyrus Poonawalla, and Christopher J. Elias World Health Organization, Regional Office for Africa, Brazzaville, Republic of Congo; World Health Organization, Geneva, Switzerland; PATH, Seattle, Washington; United Nations Children’s Fund, New York, New York; Gavi, Geneva, Switzerland; Serum Institute of India Ltd, Pune; and Bill ...

Although evolutionary change within most species is thought to occur slowly, recent studies have identified cases where evolutionary change has apparently occurred over a few generations. Anthropogenically altered environments appear particularly open to rapid evolutionary change over comparatively short time scales. Here, we consider a Pacific salmon population that may have experienced life-h...

Following the principles and priorities outlined by the World Commission on Dams, managers are increasingly considering a greater variety of impacts in their decision making regarding dams. However, many challenges remain in evaluating the biophysical, socioeconomic and geopolitical impacts of dams, including the potential diversity of stakeholder perspectives on dam impacts. In this analysis, ...

Flood disasters from dam breaks cause serious loss of human life and immense damage to infrastructure and economic stability. The application of Geographic Information System technology integrated with hydrological modeling for mapping flood-inundated areas and depth can play a momentous role in further minimizing the risk and possible damage. In the present study, base terrain data, hydrologic...

At least 13 times during the Pleistocene Epoch lava flowed into the inner gorge of the Grand Canyon and formed lava dams, as high as 600 m, that temporarily blocked the flow of the Colorado River. K-Ar ages on these lava dams indicate that the seven youngest formed within a short period of time between about 0.6 and 0.4 mega-annum (Ma). The physiography of the lava dam remnants within the canyo...

While most large river-deltas in the world are facing the risk of subsidence and erosion in the Anthropocene, it is suspected that the Changjiang submerged delta (CSD) could be subjected to the impacts of the world's largest dam, the Three Gorges Dam (TGD). Here we firstly indicate that the CSD went through high accumulation (1958-1978); slight accumulation (1978-1997), slight erosion (1997-200...