BACKGROUND Surgery for cancer of the gastrointestinal tract is associated with high morbidity and mortality, especially in older patients. A significant proportion of patients cannot be cured and would be referred for palliative therapy. Others may have early cancer but are deemed unfit for surgery. Chemotherapy and external radiotherapy are suitable for only a proportion of patients. Therefore...

Recent advances in diagnostic imaging have made it possible to detect early cancers in the gastrointestinal tract, while the development of novel antitumor agents has contributed to improved survival of patients with advanced cancers. In this review, the contents of the core symposia on 'Recent Advances in Diagnosis and Treatment for Malignancies of the Gastrointestinal Tract', held at the 6th ...

PURPOSE We evaluated the genome-wide gene expression profiles of various cancer cell lines to identify the gastrointestinal tract cancer cell-related genes. EXPERIMENTAL DESIGN Gene expression profilings of 27 cancer cell lines and 9 tissues using 7.5K human cDNA microarrays in indirect design with Yonsei reference RNA composed of 11 cancer cell line RNAs were done. The significant genes were...

Breast cancer is the second most common malignancy in women. Common sites of metastases include the liver, lung, bone, and the brain. Metastases to the gastrointestinal tract are rare with patients presenting with small-bowel perforation, intestinal obstruction, and gastrointestinal bleeding. Here we report a case of a Saudi female presenting with invasive lobular carcinoma and ileo-cecal junct...

Colorectal cancer is the third most prevalent cancer worldwide and the most common diet-related cancer, influenced by diets rich in red meat, low in plant foods and high in saturated fats. Observational studies have shown that fruit and vegetable intake may reduce colorectal cancer risks, although the precise bioactive components remain unclear. This review will outline the evidence for the rol...

neuroendocrine cells. Neuroendocrine cells are distributed throughout the gastrointestinal tract, pancreas, lung, thyroid, adrenal gland, and many other organs (1). The gastrointestinal tract has the largest population of neuroendocrine cells, but neuroendocrine malignancies are rare in the colon or rectum (2), accounting for less than 1 percent of all colorectal cancer (3). A PubMed search rev...

LY2157299 (LY), which is very small molecule bringing high cancer diffusion, is a pathway antagonist against TGFβ. LY dosage can be diluted by blood plasma, can be captured by immune system or it might be dissolved during digestion in gastrointestinal tract. The aim of our study is to optimize a "nano-elastic" carrier to avoid acidic pH of gastrointestinal tract, colon alkaline pH, and anti-imm...

background: in view of high prevalence of gi cancers in lorestan province, western iran, and a large number of esophageal cancer patients in this region, this study was done to determine the frequency of various gi cancers in the area. â  methods: in a cross-sectional study, all patients from lorestan province for whom endoscoppy and colonoscopy were performed and biopsy was provided entered ou...

<i>Fascioliasis hepatica</i> is a rare parasitic infection affecting the hepatobiliary system. On imaging examination, it presents as multiple hepatic abscesses and bile duct dilatation. Extrahepatic fascioliasis of gastrointestinal tract condition, resulting from duodenal migration fasciola flukes. The current case showed both colonic masses, mimicking colon cancer with metastasis....