A previous study has demonstrated that locally administered growth factors such as epidermal growth factor, basic fibroblast growth factor and hepatocyte growth factor can accelerate healing of experimental gastric ulcers in rats. That study indicates that locally administered growth factors can exert potent biological effects resulting in enhanced gastric ulcers healing. However, the fate of i...

Capillary gas chromatography with nitrogen-specific detection allows rapid screening of numerous drugs of toxicological interest. However, for accurate identification of individual peaks, the system must be well calibrated, e.g., through the use of retention indices (RI). To overcome problems associated with the use of RI's based on homologous series determined with nitrogen-specific detectors,...

Colloidal matrices of native and oxidized pectin were developed to improve iron bioavailability through the digestive tract. Ferrous bisglycinate (Gly-Fe), obtained by precipitation glycine chelation Fe2+, was mixed with peroxide-oxidized citrus pectin, subsequently lyophilized. Controls included without chelation. The resulting samples characterized FTIR, SEM, TGA/DSC before after in vitro dig...

The patient is a 31-year-old woman with a bulimic disorder that was not being monitored by a psychiatrist. She came to our Emergency Department due to abdominal distension and incoercible vomiting after having ingested copious amounts of food on the preceding days. On examination, the abdomen was very distended and showed tension although there was no guarding or peritoneal irritation. She pres...

The simultaneous effects of the cytochrome P450 inhibitor 1-aminobenzotriazole (ABT) on inhibition of in vivo metabolism and gastric emptying were evaluated with the test compound 7-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-3-(4-methoxy-2-methylphenyl)-2,6-dimethylpyrazolo[5,1-b]oxazole(NVS-CRF38), a novel corticotropin releasing factor receptor 1 (CRF1) antagonist with low water solubility, and the...

BACKGROUND/AIMS Lack of simple and repeatable tests hampers gastric emptying studies in rats. The aim of this study was to adapt the (14)C-octanoate solid gastric emptying breath test for application in rats, and to validate it against radioscintigraphic method. METHODS After ingestion of a meal containing 3 mCi (99m)Tc and 2 µCi (14)C-octanoate, 23 male Wistar rats were placed on a gamma cam...

Altered gastric accommodation and intestinal morphology suggest impaired gastrointestinal (GI) transit may occur in the Wistar-Kyoto (WKY) rat strain, as common in stress-associated functional GI disorders. Because changes in GI transit can alter microbiota composition, we investigated whether these are altered in WKY rats compared with the resilient Sprague-Dawley (SD) rats under basal conditi...

INTRODUCTION Metformin is an oral anti-diabetic drug in the biguanide class. The goal of this study was to develop gastric-retentive MH discs in order to prolong the retention of drug in gastric mucosa. METHODS Two groups of metformin hydrochloride (MH) mucoadhesive gastroretentive discs were prepared: (a) bilayered discs prepared by direct compression of powders containing polymers as Carbop...