The consumption of a large food bolus leads to stomach distension. Gastric distension potently signals the termination of a meal by stimulating gastric mechanoreceptors and activating neuroendocrine circuitry. The ability to terminate a meal is altered in disorders such as bulimia nervosa (BN), binge-eating disorder (BED) and certain subtypes of obesity in which large quantities of food are fre...

Glycyrrhiza glabra L. is used in folk medicine for treatment of stomach disorders includingpeptic ulcers. The hydroalcoholic extract of Glycyrrhiza glabra L. (HEGG) was evaluated forantiulcerogenic activity and acute toxicity profile in mice. Various doses of HEGG (50-200mg/kg) were administered orally to animals of different groups. Omeprazole and cimetidine atdoses of 30 and 100 mg/kg were us...

Helicobacter pylori (H. pylori) is a spiral-shaped gram negative bacterium that naturally colonizes the human gastric epithelium. In recent years, large evidence has come to the literature strongly proposing causal link between H. pylori and extra gastric disorders. Cardiovascular system is one of the extra gastric organs that can be affected by H. pylori infection. The first evidence suggestiv...

glycyrrhiza glabra l. is used in folk medicine for treatment of stomach disorders includingpeptic ulcers. the hydroalcoholic extract of glycyrrhiza glabra l. (hegg) was evaluated forantiulcerogenic activity and acute toxicity profile in mice. various doses of hegg (50-200mg/kg) were administered orally to animals of different groups. omeprazole and cimetidine atdoses of 30 and 100 mg/kg were us...

conclusions tg showed protective effect against ethanol induced gastric ulcer. this study confirmed traditional medicine claims of tg. objectives the aim of the present study was to determine the acute toxicity and protective effect of hydroalcoholic extract of tg (hetg) against ethanol induced gastric ulcer. materials and methods male wistar rats were divided into five groups (n = 7). hetg at ...

Helicobacter pylori is the main bacterial causative agent of gastroduodenal disorders and a risk factor for gastric adenocarcinoma and mucosa-associated lymphoid tissue (MALT) lymphoma. The draft genomes of 10 closely related H. pylori isolates from the multiracial Malaysian population will provide an insight into the genetic diversity of isolates in Southeast Asia. These isolates were cultured...

objective(s):this study was carried out to investigate the effects of cox-2 selective inhibitor (celecoxib) or non-selective cox inhibitor (ibuprofen) on gastrointestinal motility. materials and methods: the rats were randomly divided into five groups including: intact, sham, traumatic brain injury (tbi) group (intact rats under tbi), celecoxib group (10 mg/kg), ibuprofen group (10 mg/kg). rats...

Gastric acid is a factor in the pain associated with peptic ulcer and other acid-related disorders including functional dyspepsia, given that antisecretory treatment is a mainstay in the treatment of upper abdominal pain. However, the molecular sensors, afferent pathways and central processing systems of gastric chemonociception are little known. This article reviews emerging evidence that vaga...

H. pylori is an extracellular bacterial pathogen adapted to colonizing the gastric mucosa. It is currently recognized as the most common etiological factor involved in the genesis of digestive disorders with localization in the gastric mucosa, present in two thirds of the world population in relation to socio-economic status. The relationship between the H. pylori bacteria and the human host ca...