BACKGROUND Helicobacter pylori (HP) infection induces methylation silencing of specific genes in gastric epithelium. Various stimuli activate the nonselective cation channel TRPV4, which is expressed in gastric epithelium where it detects mechanical stimuli and promotes ATP release. As CpG islands in TRPV4 are methylated in HP-infected gastric epithelium, we evaluated HP infection-dependent cha...

SIR,-Gastric microbiology has been sadly neglected. Half the patients coming to gastroscopy and biopsy show bacterial colonisation of their stomachs, a colonisation remarkable for the constancy of both the bacteria involved and the associated histological changes. During the past three years I have observed small curved and S-shaped bacilli in 135 gastric biopsy specimens. The bacteria were clo...

Gastric ectopic pancreas is an uncommon developmental anomaly and its histological diagnosis is usually difficult by using a conventional biopsy forceps. In the literature, most cases of gastric ectopic pancreas were usually diagnosed by gross pattern during endoscopic examination or features of endoscopic ultrasound. In contrast, this disease was seldom diagnosed by histology in clinical pract...

Sarcoidosis is a multiorgan granulomatous disease of undetermined cause most commonly affecting young adults and typically characterized by pulmonary infiltrates, bilateral hilar lymphadenopathy, and cutaneous and ocular lesions. l Gastric involvement is the second most common site of gastrointestinal involvement after the liver, although the overall incidence of gastric sarcoidosis is still un...

Primary cutaneous follicle center lymphoma (PCFCL) is characterized by a proliferation of follicle center cells in the skin. A definitive diagnosis is frequently delayed because of difficulties in interpretation of the histopathologic findings. It has an excellent prognosis with a 5-year survival over 95% and its risk of transformation has not been established. We describe a case report of man ...

The aim of the study was to ascertain the existence of intestinal metaplasia in gastric mucosa of patients with gastric carcinoma coupled with H. pylori positive chronic atrophic gastritis and possible connection of IM with the development of gastric carcinoma. The paper presents prospective study that included 50 patients with gastric carcinoma and 50 patients with chronic atrophic H. pylori p...