To study the influence of activation of metabolic function of carcinogen to chemical carcinogenesis, effect of barbital, an inducer of enzymes related to drug metabolism, was studied on the development of liver cancer in the rat fed with 4-dimethylaminoazobenzene (DAB), and compared with that of 3-methylcholanthrene,*4 known to antagonize the carcinogenic effect of DAB. In an animal experiment ...

Spontaneous mammary tumour incidence, at death, of intact C3H(Jax) virgin female mice was not altered by treatment with testosterone propionate, given upto the beginning of tumour age. In 6 out of 12 mice, testosterone delayed the appearance of tumours and thus added to their longevity significantly. The type of mammary tumours obtained in testosterone-treated female mice was largely similar to...

The three slow-growing variant sublines of Yoshida sarcoma, LY-7, LY-5, and LY-336, as compared with the parent tumor, showed a marked increase in activity to synthesize glycogen from added glucose in vitro. The activity increases roughly parallel with the increasing survival time of the tumors. The glyconeogenetic activity of Yoshida sarcoma, as determined by the incorporation of pyruvate-carb...

Malignant epithelial tumors of the stomach have traditionally been classified as adenocarcinomas based upon glandular growth pattern and/or mucin positivity. Mucin positivity has been assessed by histochemical methods (PAS and Alcian Blue), both methods being unspecific. However, it is not easy to distinguish between neuroendocrine and exocrine derived malignant tumors as evidenced by the recla...

to have spoken, but found at the last moment that he was too busy, and so sent Wilkins. Watson’s plan of using his sister as bait for the unattached Wilkins failed, and Wilkins rejected his overtures. Had Wilkins been more forthcoming Watson would have ended up at King’s and not in Cambridge. Wilkins had earlier tried to persuade Randall to find a place at King’s for Crick, but the Professor ha...

DEDICATION To my Mother Su-Chu Huang, who had a near-death experience for giving birth of me, for supporting and taking care of me in every aspect of my life and make me a better person than I thought I could be. To my Father Fang-Yen Lin who taught me about Nature and science, cultivated my curiosity since I was a little kid. To my sister Tsu-Ying Lin for standing by my side all the time. And ...

Is there ever a good reason to reissue a good story? In the case of The Double Helix, the answer is emphatically yes. Forty-four years after JamesWatson published his scientific memoir of the story behind the discovery of the structure of DNA, his voice is still vibrant. And now there is more context to enjoy. The new edition, The Annotated and Illustrated Double Helix by James D. Watson, edite...

T he importance of simultaneously facilitating short-term efficiency by exploiting existing knowledge and technologies to make profits today, and long-term innovation by exploring new knowledge and technologies to adapt for future demands, is continuously highlighted in the management literature (e.g., Jansen, Tempelaar, van Den Bosch, & Volberda, 2009; March, 1991; O’Reilly & Tushman, 2013). M...

The homeodomain is a 61-amino acid protein motif present in a number of eukaryotic transcription factors (Gehring, 1987). This motif, first recognized to be encoded by some Drosophiln genes involved in development (Gehring, 1987), folds into a characteristic helix-tum-helix structure that participates in DNA binding (Kissinger et al., 1990). In plants, different strategies have led to the isola...