نتایج جستجو برای: gamma release tests

تعداد نتایج: 658394  

2015
Qing Yin Saeed El-Ashram Hongbin Liu Ximeng Sun Xinxin Zhao Xianyong Liu Xun Suo Sanjai Kumar

Early diagnosis of Toxoplasma gondii infection before the formation of tissue cysts is vital for treatment, as drugs available for toxoplasmosis cannot kill bradyzoites contained in the cysts. However, current methods, such as antibody-based ELISA, are ineffective for detection of early infection. Here, we developed an interferon-gamma release assay (IGRA), measuring the IFN-γ released by T lym...

2015
Tommy L. Camden Dora Maruffo Norma Santos John J. Nava Carlos Alcantara

On February 21, 2012, the San Antonio Metropolitan Health District (SAMHD) Tuberculosis Clinic was notified that two students at Madison High School had laboratory-confirmed pulmonary tuberculosis (TB). During March-September 2012, public health officials from SAMHD collaborated with the school district to conduct an outbreak investigation that included performing tuberculin skin tests (TSTs) o...

2011
Stamatis Katsenos Melita Nikolopoulou Georgia Tsiouri Ioannis D Bassukas Stavros H Constantopoulos

It is well-established that tumour necrosis factor (TNF)-α-antagonist regimens are advisable for the control of moderate to severe psoriasis; however the application of these agents is associated with increased risk of TB reactivation. Screening for latent tuberculosis infection (LTBI) is indispensable prior to treatment inception in order to diminish the risk of active TB. Although tuberculin ...

2016
Chung-Jong Kim Eun Jung Kim Kyoung-Ho Song Pyoeng Gyun Choe Wan Beom Park Ji Hwan Bang Eu Suk Kim Sang Won Park Hong-Bin Kim Myoung-don Oh Nam Joong Kim

BACKGROUND Differences between the characteristics of culture positive pyogenic spondylitis (CPPS) and tuberculous spondylitis (TS) are well known. However, differences between the characteristics of culture negative pyogenic spondylitis (CNPS) and TS have not been reported; these would be more helpful in clinical practice especially when initial microbiologic examination of blood and/or biopsy...

Journal: :The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 2014
K Paquette M P Cheng M J Kadatz V J Cook W Chen J C Johnston

SETTING In low-incidence regions, tuberculosis (TB) often affects vulnerable populations. Guidelines recommend active case finding (ACF) in homeless populations, but there is no consensus on a preferred screening method. OBJECTIVE We performed a systematic review and meta-analysis to evaluate the use of chest X-ray (CXR) screening in ACF for TB in homeless populations. DESIGN Articles were ...

2014
Winsley Rose Ian Kitai Fatima Kakkar Stanley E Read Marcel A Behr Ari Bitnun

BACKGROUND HIV infected children are at increased risk of TB disease and require annual TB screening. Data on use of IGRA for TB screening in them are limited. We retrospectively evaluated the usefulness of Quantiferon Gold-in-tube test (QFT), an IGRA in screening for LTBI in relatively healthy, immunologically stable HIV infected children. METHODS HIV infected children with no prior history ...

Journal: :Thorax 2013
Ibrahim Abubakar Helen Ruth Stagg Hilary Whitworth Ajit Lalvani

BACKGROUND Interferon gamma release assays (IGRAs) are the first new diagnostic tests for latent tuberculosis (TB) infection (LTBI) since the century-old tuberculin skin test (TST). They are cell-mediated immune-based blood tests that have revolutionised LTBI diagnosis and are increasingly recommended by national guidelines. OBJECTIVES With the rapid expansion of the IGRA evidence-base in rec...

Journal: :Thorax 2010
J Eriksen J Y Chow V Mellis B Whipp S Walters E Abrahamson I Abubakar

BACKGROUND In July 2008 a case of smear-positive pulmonary tuberculosis (TB) in a white UK-born nursery teacher was notified in London. The case had been symptomatic for 9 months while working in the nursery. The outbreak is described and the protective effect of BCG vaccination against latent Mycobacterium tuberculosis infection as measured by an interferon gamma release assay (IGRA) is assess...

2014
A Roy M Eisenhut R J Harris L C Rodrigues S Sridhar S Habermann L Snell P Mangtani I Adetifa A Lalvani I Abubakar

OBJECTIVES To determine whether BCG vaccination protects against Mycobacterium tuberculosis infection as assessed by interferon γ release assays (IGRA) in children. DESIGN Systematic review and meta-analysis. Searches of electronic databases 1950 to November 2013, checking of reference lists, hand searching of journals, and contact with experts. SETTING Community congregate settings and hou...

Journal: :Communicable diseases intelligence quarterly report 2011
James M Trauer Krispin M Hajkowicz Kevin G Freeman Vicki L Krause

Although the tuberculin skin test (TST) has been the mainstay of the diagnosis of latent tuberculosis infection (LTBI) for many decades, interferon-gamma release assays (IGRAs) are gaining acceptance and are more specific for this diagnosis. The characteristics of one such IGRA, the QuantiFERON-TB Gold Whole Blood In-Tube, make it feasible for use in a remote setting. This study performed 62 IG...

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