Joanna E. Cygler, Jan Seuntjens, J. Daniel Bourland, M. Saiful Huq, Josep Puxeu Vaque, Daniel Zucca Aparicio, Tatiana Krylova, Yuri Kirpichev, Eric Ford, Caridad Borras Stereotactic Radiation Therapy (SRT) utilizes small static and dynamic (IMRT) fields, to successfully treat malignant and benign diseases using techniques such as Stereotactic Radiosurgery (SRS) and Stereotactic Body Radiation T...

background: accurate voxel phantom is needed for dosimetric simulation in radiation therapy for malignant tumors in female pelvic region. however, most of the existing voxel phantoms are constructed on the basis of caucasian or non-chinese population. materials and methods: a computational framework for constructing female pelvic voxel phantom for radiation dosimetry was performed based on chin...

introduction the gamma knife system is designed solely for non-invasive treatment of brain disorders, and it benefits from stereotactic surgical techniques. dose calculations required in the system are performed by gammaplan code; in this code, brain tissue is considered uniform. in the present study, we evaluated the effect of gamma knife system on the obtained dose through simulating a real h...

abstract background: adjacent treatment fields are commonly used in external beam radiation therapy, such as mantle and inverted-y fields for the treatment of hodgkin’s disease and craniospinal fields used in the treatment of medulloblastoma and head and neck tumors when the lateral neck fields are placed adjacent to the anterior supraclavicular field. in each of these situations, there is a po...

background: in conventional radiation therapy, regarding normal tissue tolerance, the treatment of bulk tumors is one of the remaining challenges. grid radiation therapy (grt) is a technique to deliver high doses, approximately 15 – 20 gy per fraction, to several small volumes located in a large radiation field. this can be performed using a grid block. the current work has concentrated on the ...

In terms of biological dosimetry at the time of radiation exposure, the dicentric chromosome (Dic) assay (DCA) is the gold standard for assessing for the acute phase and chromosome translocation (Tr) analysis is the gold standard for assessing the chronic phase. It is desirable to have individual dose-response curves (DRCs) for each laboratory because the analysis criteria differ between labora...

apoptosis, a physiologic mechanism to eliminate unwanted cells, is also induced by ionizing irradiation, through production of free radicals. it has been demonstrated that antioxidants such as vitamin e are able to protect cells from damage caused by free radicals. taken together we found it reasonable to make an attempt to evaluate the protective effect of vitamin e against apoptosis. the irra...

Various bacterial spores exhibited a wide range of radiation resistance to doses of 0.25 to 2.5 Mrad from a cobalt-60 radiation facility. Bacillus pumilus and Clos-tridium tetani were shown to have the highest degree of resistance when compared with other bacterial sporeformers. B. subtilis E163 was the least resistant of the bacterial spores studied. Dried spores contained on cellulose discs w...

Background: In radiation therapy, water is the phantom material of choice, both for reference and for relative dosimetry measurements. Solid phantoms, however, are more useful for routine measurements because they tend to be more robust and easier to set up than water phantoms. Materials and Methods: FLUKA input data cards have been arranged in sequential order. A simple cylindrical geometry wi...

background: humans beings are continuously exposed to ionizing radiation from natural sources. the main contributors to natural radiation are high-energy cosmic radiation and radioactive nuclides that originates in the earth’s crust. exposure to high levels of radiation can cause serious health effects. in this study an attempt has been made to monitor the levels of environmental background rad...