Electropolymerization of novel gallium Schiff-base complexes results in conducting metallopolymers containing either coordinatively saturated or unsaturated gallium metal centers. Depending on the chemical coordination of the metal centers, the embedded metal ions can act as seed points for the direct growth of size-controlled gallium sulfide nanoparticles in a conducting polymer, yielding a hy...

Glucan particles (GPs) are hollow, porous 3-5 μm microspheres derived from the cell walls of Baker's yeast (Saccharomyces cerevisiae). The 1,3-β-glucan outer shell provides for receptor-mediated uptake by phagocytic cells expressing β-glucan receptors. GPs have been used for macrophage-targeted delivery of a wide range of payloads (DNA, siRNA, protein, small molecules, and nanoparticles) encaps...

Combination chemotherapy forms the backbone of cancer treatment. There is a need for new drug combinations for the treatment of mantle cell lymphoma (MCL). Herein, we show that gallium maltolate, a novel gallium compound, synergizes with bortezomib, a proteasome inhibitor, to induce cell death in MCL Granta cells. Cells exposed to either agent displayed caspase-3 activation, a loss of mitochond...

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The reasons why aminoglycosides are bactericidal have not been not fully elucidated, and evidence indicates that the cidal effects are at least partly dependent on iron. We demonstrate that availability of iron markedly affects the susceptibility of the facultative intracellular bacterium Francisella tularensis strain SCHU S4 to the aminoglycoside gentamicin. Specifically, the intracellular dep...

A series of molecular gallium compounds were analyzed using X-ray photoelectron spectroscopy (XPS). Specifically, the Ga 2p3/2 and Ga 3d5/2 photoelectron binding energies and the Ga L3M45M45 Auger electron kinetic energies of compounds with gallium in a range of assigned oxidation numbers and with different stabilizing ligands were measured. Auger parameters were calculated and used to generate...

The melting point of gallium (29.7646 °C) is a defining thermometric fixed point of the International Temperature Scale of 1990 (ITS-90). Realization of this melting point is performed using a fixedpoint cell containing high-purity (≥99.999 99 wt. % pure) gallium. A 30 kg single lot of gallium (99.999 9956 wt. % pure) constituting Standard Reference Material (SRM) 1751 was evaluated, and certif...

Received 10/21/2000; revised 11/14/2000; accepted 11/21/2000 For correspondence or reprints contact: Dong-Ling You, M.D., Department of Nuclear Medicine, Sun Yat-Sen Cancer Center, 125, Lih-Der Road, Pei-Tou District, Taipei, Taiwan. Tel: (886)2-28970011 ext. 1110, Fax: (886)2-28971100, E-mail: [email protected] Granulocytic sarcoma is an extramedullary tumor of myeloproliferative precurso...

Gallium 67 citrate was evaluated with conventional scanning and emission computed tomography (CT) scanning as a method of pretreatment staging of the intrathoracic, especially mediastinal, spread of lung cancer. Of 31 patients with tumours of various histological types, the isotope was concentrated in the primary lesion in all but one. In 10 out of 12 patients who underwent surgical exploration...