introduction: toxoplasma gondii (t. gondii) is distributed worldwide and infects most species. the serious incidence and severe or fatal injury caused by t. gondii infection clearly indicates the necessity for the event of a vaccine. the current study goals were to evaluate serological applications of toxoplasma gondiirhoptry protein 1 (rop1) antigen. materials and methods: we created a polymer...

coincidental occurrence of hepatocellular carcinoma (hcc) and cholangiocarcinoma, known as “collision tumors”, within a cirrhotic liver is rare. herein, we report a case of liver transplantation (lt) in a patient with such collision tumors. our patient was a 56-year-old woman with hepatitis c virus-related cirrhosis and 2 focal hepatic lesions, measuring 1.5 and 3 cm, in the liver segments 8 an...

literature review shows that hepatitis c infection may increase the risk of non-hodgkin lymphoma. reactivation of hepatitis b infection has been reported in patients with hairy cell leukemia after chemotherapy and/or splenectomy. we present hepatitis b surface (hbs) antigenemia and concurrent hepatitis c virus (hcv) seropositivity in a case of hairy cell leukemia. key words: hairy cell leukemia...

to determine the normal ranges of serum age-related prostate-specific antigen (psa) level in men from beijing area without cancer.in this cross sectional study, form april 2010 to october 2011, 1611 healthy men undergoing a routine health check-up in our hospital and all men received three examinations including serum psa test, digital rectal ex-amination and transrectal ultrasound. men with an...

background: dna immunization with plasmid dna encoding bacterial, viral, parasitic and tumor antigens has been reported to trigger protective immunity. objective: to evaluate the use of a dna immunization strategy for protection against anthrax, a plasmid was constructed. methods: the partialsequence of protective antigen of bacillus anthracis, amino acids 175-764, as a potent immunogenic targe...

tuberculosis remains as an important socioeconomical and medical problem throughout the world and especially in iran. early and timely diagnosis of pulmonary and extrapulmonary tuberculosis is vital to initiate prompt treatment. current diagnostic methods are either slow or lack enough sensitivity or specificity. several mycobacterial antigens are involved in the complex interaction with the im...

background: human leukocyte antigen-e (hla-e)is a non-classical major histocompatibility complex (mhc) class i antigens which expressed on extra villous cytotrophoblast, which interacts with nkg2a, is an inhibitory receptor on natural killer (nk) cells and leading to down regulation of immune response in the maternal-fetal interface and provides maternal immune tolerance of the fetus. objective...

background: cystic echinococcosis caused by the metacestode of echinococcus granulosus is a major problem in both humans and domestic animals health. there-fore, a standardized and approachable diagnostic tool (rapid tests) for the serodiag-nosis of cystic echinococcosis (ce) is still needed. methods: in the present work, antigen b labeled with gold nanoparticles was used to detect antibodies a...