Background & Aims: Helicobacter pylori (H. pylori) infection is associated with peptic ulcer and gastric cancer. Polymorphisms of the genes coding Toll-like receptors (TLRs) may influence the innate and adaptive immune responses and affect the susceptibility to H. pylori or the disease outcomes. But the details and association to different polymorphis...

BACKGROUND: Interaction between estrogen and receptor (ER) takes part in the regulation differentiation of breast tumorigenesis. Some ERα polymorphisms, including rs3798577, are reported to be associated with risk aggressiveness carcinoma since site was targeted by microRNA, which can further modulate expression. Hence, this study conducted disclose possible role SNP rs3798577 on patients.METHO...

Molecular markers and mapping are used to analyze an organism’s genes. They allow the selection of target genetic areas based on marker genotype (and not trait phenotype), facilitate study variability diversity, create linkage maps, follow individuals or lines carrying certain may be select parental genotypes, remove drag in back-crossing, choose difficult-to-measure characteristics. Due a lack...

background: human cornea expresses functional fas-ligand capable of killing fas+ activated lymphocytes. fas expression is partly regulated by -670 a/g polymorphism in the promoter region of fas gene. objective: the aim of the present study is to determine the association between fas-670a/g polymorphism and survival of corneal transplantation. methods: in 276 graft recipients who mainly underwen...

conclusions il6 and il8 gene polymorphisms have no role in nash pathogenesis and liver fibrosis process, but presence of the a/a genotype in the il8 gene is associated with disease progression. patients and methods consecutive patients with biopsy proven nash and age- and gender-matched healthy individuals with normal liver function tests and normal ultrasonography were enrolled in the study. h...

the aim of this study was to analyze 22 cytokine polymorphisms in the roma population from the republic of macedonia. the roma population consists of 77 healthy unrelated individuals, residents of different geographical regions of the republic of macedonia (skopje, gostivar, and kochani). blood samples were collected after obtaining written consent. dna was isolated from peripheral blood and 22...

background: polymorphisms in the immune related genes are important in the clinical outcome of helicobacter pylori infection. myeloperoxidase -463 g/a polymorphism has been shown to reduce enzyme expression and activity. objective: the aim of the present study is to investigate the association of myeloperoxidase g-463a polymor-phism with clinical outcome of helicobacter pylori infection. method...

objective: to determine the possible association between the m235t variant of angiotensinogen gene and preeclampsia in iranian preeclamtic women with hypertension during pregnancy. mand methods: during a case control study, we used polymerase chain reaction-based restriction fragment length polymorphism (pcr-rflp) analysis to investigate the association between m235t polymorphism in preeclamtic...