The therapeutic efficacy of long-circulating polyethylene glycol-coated liposomal amphotericin B (AMB) (PEG-AMB-LIP) was compared with that of AMB desoxycholate (Fungizone) in a model of severe invasive pulmonary aspergillosis in persistently leukopenic rats as well as in temporarily leukopenic rats. PEG-AMB-LIP treatment (intravenous administration) consisted of a single, or double (every 72 h...

Resistance to pentavalent antimonial (Sb(v)) agents such as sodium stibogluconate (SSG) is creating a major problem in the treatment of visceral leishmaniasis. In the present study the in vivo susceptibilities of Leishmania donovani strains, typed as SSG resistant (strain 200011) or SSG sensitive (strain 200016) on the basis of their responses to a single SSG dose of 300 mg of Sb(v)/kg of body ...

background menstrual blood-derived stem cells (menscs) are a novel source of stem cells that can be easily isolated non-invasively from female volunteered donor without ethical consideration. these mesenchymal-like stem cells have high rate of proliferation and possess multi lineage differentiation potency. this study was undertaken to isolate the menscs and assess their potential in differenti...

Amphotericin B and other polyene antibiotics have been shown to be useful agents for the isolation of auxotrophic mutants of yeast by virtue of their ability to selectively eliminate large numbers of wild-type cells from mixed populations (A. G. Moat, I. J. Barnes, and E. H. McCurley, J. Bacteriol. 92:297, 1966; A. G. Moat, N. Peters, and A. M. Srb, J. Bacteriol. 77:673, 1957; R. Snow, Nature 2...

S urgical treatment of coccidioidomycosis is recognized as a proved method of curative therapy. However, there is not universal agreement as to the specific method of management. The decision regarding management is made on personal experience and judgment and this varies with the individual surgeon. In general, the division on methodology hinges on an opinion regarding administration of amphot...

Amphotericin B (AmB) has toxic effects and alters neutrophil (polymorphonuclear leukocyte [PMN]) function. A lipid-complexed formulation of AmB (AmB-LC) has been reported (A. S. Janoff, L. T. Boni, M. C. Popescu, S. R. Minchey, P. R. Cullis, T. D. Madden, T. Taraschi, S. M. Gruner, E. Shyamsunder, M. W. Tate, R. Mendelsohn, and D. Bonner, Proc. Natl. Acad. Sci. USA 85:6122-6126, 1988) to be les...

BACKGROUND & OBJECTIVE Bihar State of India has been an endemic State for kala-azar. There has been many phases of DDT sprays for vector control. An outbreak of kala-azar occurred in Goanpura, 6 km from Patna, Bihar, in 2003. We undertook this study with a new approach of kala-azar elimination in this village with priority to treatment of cases followed by supplementation with supervised DDT sp...

The purpose of this study is to clarify the presence of so much insoluble microparticles in the injections and to confirm the usefulness of the final filter for its removal. The test drugs used were Doyle 1 g vial, Cefotax 1 g vial, Minomycin 100 mg vial, Omegacin 0.3 g vial, Maxipime 1 g vial, Rocephin 1 g vial, Isovorin 25 mg vial, Diamox 500 mg vial and Fungizone 50 mg vial. 1) An appropriat...

The polyene antibiotic Amphotericin B (AMB) is one of the first therapeutic agents to be marketed commercially as nanosized formulations in which the drug is associated with lipids as liposomes or complexes. In this way, its renal toxicity is reduced and its therapeutic index improved. This review summarizes the particular properties of AMB which justify this type of formulation and the early w...

Virologic, serologic and clinical records at two Montreal hospitals revealed 19 adults and 27 children with influenza A2 (Hong Kong variant) .mfections during the winter months of 1971/72. Serious disease and two deaths were encountered in 14 (51 percent) children with underlying disease and 15 (55 percent) below three years of age. S i x (22 percent) children had pneumonia, nine (33 percent) g...