Keratitis is an inflammatory condition, characterized by involvement of corneal tissues. Most recurrent challenge of keratitis is infection. Bacteria, virus, fungus and parasitic organism have potential to cause infection. TLR are an important class of protein which has a major role in innate immune response to combat with pathogens. In last past years, extensive research efforts have provided ...

Diagnosis of Pythium keratitis is problematic due to the difficulty in obtaining a culture report resulting in unnecessarily prolonged usage of antimicrobial medication due to misdiagnosis. This study evaluated and compared nested PCR technique with culture and immunoperoxidase staining assays of Pythium insidiosum in paraffin-embedded corneal tissues from patients with suspected fungal keratit...

BACKGROUND AND PURPOSE Fungal keratitis is a suppurative, ulcerative, and sight-threatening infection of the cornea that sometimes leads to blindness. The aims of this study were: recuperating facilities for laboratory diagnosis, determining the causative microorganisms, and comparing conventional laboratory diagnostic tools and semi-nested PCR. MATERIALS AND METHODS Sampling was conducted in...

PURPOSE To report the predisposing risk factors, clinical presentation, management, and therapeutic outcomes of fungal keratitis caused by Acremonium. METHODS This is a retrospective study of cases with Acremonium fungal keratitis that presented to our tertiary referral center between January 2006 and August 2012. Patient demographic and clinical details were determined and reported. RESULT...

Abstract Fungal keratitis is challenging to diagnose and treat remains a significant cause of blindness worldwide. The easiest most common method drug delivery for patients with fungal eye drop administration. However, the therapeutic effect traditional drops unsatisfactory, largely due intrinsic nature ocular barriers, which limit absorption; rapid decrease in concentration caused by tears; si...

The purpose of this study was to describe the clinical characteristics of fungal keratitis caused by Candida albicans in an eye after Descemet stripping automated endothelial keratoplasty (DSAEK). A 72-year-old male with a history of three trabeculectomies, cataract surgery, and two DSAEK procedures developed a corneal ulcer in his right eye two years after his last DSAEK. Fungal keratitis was ...

PURPOSE To identify the most common etiologies of corneal disease and the risk factors associated with worse visual outcomes in Changsha, Hunan, located in southern China. METHODS This observational, cross-sectional study evaluated 100 consecutive patients seen at the cornea clinic of The Second Xiangya Hospital of Central South University. Ocular history, demographic information, and ocular ...

Keratomycosis is a major cause ofvisual disability in developing countries(1). It is common in our country because of the tropical climate and a large agrarian population at risk. Since the first report ofkeratomycosis. by Professor Theodor Leber, fungi have been increasingly implicated in the cause ofcorneal ulcer (2,3), there has been a dramatic rise in frequency of these infections in the la...