نتایج جستجو برای: fungal biotransformation

تعداد نتایج: 57641  

Journal: :Environmental science & technology 2012
Yung-Shan Lee S Victoria Otton David A Campbell Margo M Moore Chris J Kennedy Frank A P C Gobas

Methods for rapid and cost-effective assessment of the biotransformation potential of very hydrophobic and potentially bioaccumulative chemicals in mammals are urgently needed for the ongoing global evaluation of the environmental behavior of commercial chemicals. We developed and tested a novel solvent-free, thin-film sorbent-phase in vitro dosing system to measure the in vitro biotransformati...

Journal: :Drug discovery today 2010
Danyel G J Jennen Stan Gaj Pieter J Giesbertz Joost H M van Delft Chris T Evelo Jos C S Kleinjans

In recent decades, our knowledge of the genetics and functional genomics of drug-metabolizing enzymes has increased and a wealth of data on drug-related 'omics' has become available. Despite the availability of large amounts of biological information on xenobiotic biotransformation, the number of available biotransformation pathway maps that can easily be used for visualization of multiple omic...

Journal: :Toxicological sciences : an official journal of the Society of Toxicology 2000
V S Wilson G A LeBlanc

Hepatic biotransformation processes can be modulated by chemical exposure and these alterations can impact the biotransformation of endogenous substrates. Furthermore, chemically mediated alterations in the biotransformation of endogenous steroid hormones have been implicated as a mechanism by which steroid hormone homeostasis can be disrupted. The fungicide ketoconazole has been shown to lower...

Journal: :Journal of hazardous materials 2009
Jen-Chieh Tsai Mathava Kumar Jih-Gaw Lin

In the present study, anaerobic biotransformation of fluorene and phenanthrene by sulfate-reducing bacteria (SRB) was investigated and biotransformation pathways were proposed. SRB was enriched from anaerobic swine wastewater sludge and its abundance was determined by the fluorescence in situ hybridization (FISH) technique. Batch anaerobic biotransformation studies were conducted with fluorene ...

2000
Walt W. McNab

Biotransformation of dissolved groundwater hydrocarbon plumes emanating from leaking underground fuel tanks should, in principle, result in plume length stabilization over relatively short distances, thus diminishing the environmental risk. However, because the behavior of hydrocarbon plumes is usually poorly constrained at most leaking underground fuel tank sites in terms of release history, g...

Journal: :Drug metabolism and disposition: the biological fate of chemicals 2005
Xiuling Zhang Qing-Yu Zhang Dazhi Liu Ting Su Yan Weng Guoyu Ling Ying Chen Jun Gu Boris Schilling Xinxin Ding

Despite recent progress in the identification and characterization of numerous nasal biotransformation enzymes in laboratory animals, the expression of biotransformation genes in human nasal mucosa remains difficult to study. Given the potential role of nasal biotransformation enzymes in the metabolism of airborne chemicals, including fragrance compounds and therapeutic agents, as well as the p...

Kanhiya Mahour, Prabhu N Saxena,

Introduction: The fate of xenobiotics that is present, increasing day by day. The increasing fates altered or inhibit the metabolic activities like detoxification and biotransformation. Methods: The present study highlights this slow biotransformation and detoxification on the basis of specific enzymes which have a say in assessment of mercuric chloride toxicity and modulation by Panax ginse...

Journal: :environmental health engineering and management 0
ali asghar najafpoor health sciences research center, department of environmental health engineering, school of health, mashhad university of medical sciences, mashhad, iran abbas sadeghi health sciences research center, department of environmental health engineering, school of health, mashhad university of medical sciences, mashhad, iran hossein alidadi health sciences research center, department of environmental health engineering, school of health, mashhad university of medical sciences, mashhad, iran mojtaba davoudi health sciences research center, department of environmental health engineering, school of health, mashhad university of medical sciences, mashhad, iran batoul mohebrad environmental health engineering, school of health, mashhad university of medical sciences, mashhad, iran ahmad hosseinzadeh environmental health engineering, student research committee, school of health, mashhad university of medical sciences. mashhad, iran

background: phenol, as a pure substance, is used in many fields because of its disinfectant, germicidal, local anesthetic, and peptizing properties. aqueous solutions of phenol are produced as waste in industries and discharged into the environment. therefore, elevated concentrations of phenol may be found in air or water because of industrial discharge or the use of phenolic products. method: ...

2016
Lei Yan Peng Chen Shuang Zhang Suyue Li Xiaojuan Yan Ningbo Wang Ning Liang Hongyu Li

We performed the biotransformation of ferulic acid to vanillin using Bacillus subtilis (B. subtilis) in the stirring packed-bed reactors filled with carbon fiber textiles (CFT). Scanning electron microscope (SEM), HPLC, qRT-PCR and ATP assay indicated that vanillin biotransformation is tightly related to cell growth, cellar activity and the extent of biofilm formation. The biotransformation was...

Journal: :Toxicology and applied pharmacology 2003
Esther F A Brandon Christiaan D Raap Irma Meijerman Jos H Beijnen Jan H M Schellens

The liver is the predominant organ in which biotransformation of foreign compounds takes place, although other organs may also be involved in drug biotransformation. Ideally, an in vitro model for drug biotransformation should accurately resemble biotransformation in vivo in the liver. Several in vitro human liver models have been developed in the past few decades, including supersomes, microso...

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