Correspondence: Aditi Gupta Shri Bhagwan Mahavir Department of Vitreoretinal Services, Sankara Nethralaya, 18 College Road, Chennai 600 006, Tamil Nadu, India Tel +91 44 2827 1616 Fax +91 44 2825 4180 Email [email protected] We read with great interest the recent article by Kashima et al, in which the authors report a case of asymmetric severity of diabetic retinopathy in Waardenburg synd...

Fuchs' theory Ernst Fuchs, who first described this disease in 1906, assumed that the syndrome was caused by a noxious factor of unknown origin, which was active from fetal or early postnatal life.' First, the normal development of uveal pigmentation would be inhibited, resulting in heterochromia (Fig 1). Later, the eye would respond to this pathological agent by a low grade inflammation. Many ...

PURPOSE To characterize the polyspecific intraocular antibody synthesis in aqueous humor of patients with chronic inflammatory diseases of the eye and to detect the causative antigen in Fuchs heterochromic cyclitis (FHC). DESIGN Retrospective case-control study. METHODS Intraocular antibody synthesis is detected in aqueous humor with the Antibody Index [AI] (improved Goldmann-Witmer Index) ...

BACKGROUND Fuchs heterochromic cyclitis (FHC) is a chronic inflammatory eye disease, usually presenting as unilateral anterior uveitis. Up to date no disease susceptibility genes have been described for FHC. METHODS The allele frequency of HLA DRB1 and DQB1, polymorphisms of the tumour necrosis factor (TNF) alpha promoter region (-376, -308, -238), the promoter (-318), first exon (+49) and (A...

of oculomotor and trochlear nerve involvement have also been reported.' With intracranial hypertension, changes in seventh nerve function are exceptional. Peripheral facial nerve palsy was observed in five individuals suffering from benign intracranial hypertension.78 In one additional patient facial myokymia has been observed, thus showing that, with intracranial hypertension, facial nerve inv...

We have studied the antigen frequencies in a group of adult patients with acute and chronic iridocyclitis and chronic, cyclitis. In patients with iridocyclitis a statistically significant increased incidence of HLA-B27 was noted, even in those patients without joint or systemic disease. Patients with chronic iridocyclitis also were noted to have an increased incidence of B27; however, those pat...

AIMS To determine whether macrophage migration inhibitory factor (MIF) levels were increased in sera of the patients with iridocyclitis. METHODS Sera were obtained from 41 patients with acute iridocyclitis, 13 patients with chronic iridocyclitis, and 44 healthy control subjects. MIF levels were determined by a human MIF ELISA. RESULTS The average levels of MIF in the sera of patients with b...

T cell mediated immune responses against the cornea specific protein BCP 54 have been observed in patients with uveitis, Fuchs' heterochromic cyclitis, and corneal disease. The pathophysiological role of this anti-BCP 54 response in corneal disease is not known. In order to ascertain whether the presence of such an immune response is related to the corneal disease itself or related to genetic i...