FTIR difference spectroscopy is widely used to probe molecular bonding interactions of protein-bound electron transfer cofactors. The technique is particularly attractive because it provides information on both neutral and radical cofactor states. Such dual information is not easily obtainable using other techniques. Although FTIR difference spectroscopy has been used to study cofactors in biol...

The N-terminal domain of HIV-1 glycoprotein 41,000 (gp41) participates in viral fusion processes. Here, we use physical and computational methodologies to examine the secondary structure of a peptide based on the N terminus (FP; residues 1-23) in aqueous and detergent environments. (12)C-Fourier transform infrared (FTIR) spectroscopy indicated greater alpha-helix for FP in lipid-detergent sodiu...

Rapid advances in imaging technologies have pushed novel spectroscopic modalities such as Fourier transform infrared spectroscopy (FTIR) and X-ray absorption spectroscopy (XAS) at the sulfur K-edge to the forefront of direct in situ investigation of brain biochemistry. However, few studies have examined the extent to which sample preparation artifacts confound results. Previous investigations u...

Background. FTIR spectroscopy is becoming an important tool in the differentiation and identification of bacteria. In the present study, lactic acid bacteria of the genus Leuconostoc were differentiated and identified with the use of Fourier transform infrared spectroscopy (FTIR) and artificial neural networks (ANNs). The aim of the study was to expand the existing library of FTIR spectra of la...

BACKGROUND Oleaginous fungi can accumulate lipids by utilizing a wide range of waste substrates. They are an important source for the industrial production of omega-6 polyunsaturated fatty acids (gamma-linolenic and arachidonic acid) and have been suggested as an alternative route for biodiesel production. Initial research steps for various applications include the screening of fungi in order t...

Arsenic exposure results in several human cancers, including those of the skin, lung, and bladder. As skin cancers are the most common form, epidermal keratinocytes (KC) are the main target of arsenic exposure. The mechanisms by which arsenic induces carcinogenesis remains unclear, but aberrant cell proliferation and dysregulated energy homeostasis play a significant role. Protein glycosylation...

Counterfeit pharmaceuticals are of concern internationally. In certain regions of the world, the percentage of counterfeit pharmaceuticals present in the consumer marketplace is troubling. For this reason, active testing programs are in place, and they tend to rely on classical analysis methods such as chromatography and wet chemistry. These methods can be time-consuming, labor intensive, and t...

We present SLAP, a system of tangible, translucent widgets for use on FTIR-based multi-touch tabletops. Our initial widgets include a SLAP keyboard, button, slider, knob, and lens. SLAP widgets add tactile feedback to multi-touch tables, improving input accuracy. They can be relabeled dynamically via table rear projection, and provide inexpensive, battery-free, and untethered augmentations for ...

Isotope-edited FTIR spectroscopy has been shown to be able to determine peptide's structure in the residue level in D2O, which is not a physiological solvent. Here, attenuated total reflection technique was utilized to successfully apply isotope-edited FTIR spectroscopy in H2O to determine the conformation of specific residues in a model peptide.

A new instrumental method for the quantitative measurement of acid content AC in mineralbased lubricants was devised by employing FTIR spectroscopy, with AC serving as an alternative to traditional acid number AN measures commonly made to assess lubricant quality. The method involves the addition of an oil-immiscible ethanolic solution of the base sodium hydrogen cyanamide NaHN–CwN to the lubri...