In two patients with congenital isolated thyrotropin (TSH) deficiency, serum TSH determined by a sensitive immunoradiometric assay (IRMA) was consistently undetectable. The basal levels of serum free TSH-alpha subunit (TSH-alpha) determined by a specific radioimmunoassay (RIA) were elevated in the hypothyroid state, and decreased to the undectable level during displacement therapy with thyroid ...

results apoptosis induced by pa in ins-1 cells was significantly resolved after liraglutide treatment. simultaneously, autophagy was enhanced with the treatment of pa and liraglutide. conclusions: liraglutide appears to protect ins-1 cells from apoptosis ffa-induced by promoting autophagy. conclusions these findings provide a novel role for glp-1 analogue in preventing or treating with t2d. obj...

Vitexin (1), isovitexin (2), orientin (3), isoorientin (4) and 1,3dihydroxy6, 7dimethoxyxanthone (5) were isolated from the whole plant of Begonia picta, a Nepalese crude drug commonly known as “Magarkaanche”. Structures were elucidated on the basis of chemical and spectroscopic methods. All of these compounds were isolated for the first time from B. picta and their in vitro antioxidant acti...

The alpha and beta subunits of human chorionic gonadotropin are secreted both as a combined, noncovalently linked dimer form as well as uncombined, free forms by human trophoblastic cells. We have utilized the cultured choriocarcinoma cell line JAR to determine what regulates the combination of the two subunits. The human chorionic gonadotropin subunits produced by JAR cells were biosynthetical...

A method is presented to separate the mRNAs coding for alpha and beta globins of rabbit reticulocytes. 10S RNA was extracted from the light and heavy polysomes created by incubation of reticulocytes with L-O-methylthreonine, and assayed for mRNA activity in an ascites cell-free extract. Tryptic digests of the in vitro products demonstrated that the heavy polysomes yielded beta globin mRNA at le...

 The category of the title is called $mathcal{W}$. This has all free objects $F(I)$ ($I$ a set). For an object class $mathcal{A}$, $Hmathcal{A}$ consists of all homomorphic images of $mathcal{A}$-objects. This note continues the study of the $H$-closed monoreflections $(mathcal{R}, r)$ (meaning $Hmathcal{R} = mathcal{R}$), about which we show ({em inter alia}): $A in mathcal{A}$ if and  only if...

Placenta growth factor (PIGF), an angiogenic factor belonging to the vascular endothelial growth factor family, pregnancy-associated plasma protein A (PAPP-A) and free beta-human chorionic gonadotrophin (beta-hCG) were measured in maternal serum from 45 pregnancies with trisomy 21, 45 with trisomy 18 and 493 normal controls at 10-13 completed weeks of gestation. In the normal pregnancies matern...