Fragility functions, as new measures for estimating structural damage and casualties due to tsunami attack, are developed by an integrated approach using numerical modeling of tsunami inundation and GIS analysis of post-tsunami survey data of the 2004 Sumatra– Andaman earthquake tsunami disaster, obtained from Banda Aceh, Indonesia. The fragility functions are expressed as the damage probabilit...

Fragility curves for retrofitted bridges indicate the influence of various retrofit measures on the probability of achieving specified levels of damage. This paper presents an analytical methodology for developing fragility curves for classes of retrofitted bridge systems. The approach captures the impact of retrofit on the vulnerability of multiple components, which to date has not been adequa...

The aim of this study was to assess the usefulness of the inbred rat model for studies of genetic influences on skeletal fragility. We characterized bone mass, geometry, and skeletal biomechanics in 11 inbred strains of rats. This study showed that considerable variation exists in bone structure, areal bone mineral density (aBMD), and fragility phenotypes among inbred strains of rats. Interesti...

We examine the sensitivity and surface bias of convolved DGLV radiative and elastic loss in a realistic geometry including Bjorken expansion. We find that this more faithful treatment of the medium density is not a priori reproducible via fixed length approximations, and neither the fragility nor the surface emission of BDMPS-based models is seen.

Robustness, a long-recognized property of living systems, allows function in the face of uncertainty while fragility, i.e., extreme sensitivity, can potentially lead to catastrophic failure following seemingly innocuous perturbations. Carlson and Doyle hypothesized that highly-evolved networks, e.g., those involved in cell-cycle regulation, can be resistant to some perturbations while highly se...

INTRODUCTION The prevention of fragility fractures in patients with sarcoidosis is a serious concern and the potential risk of hypercalcemia limits vitamin D and calcium supplementation. The objective of this study was to evaluate the risk factors for low bone mineral density (BMD) and fractures in sarcoidosis. In particular, we aimed to determine the link among bone fragility and calcium and v...