نتایج جستجو برای: fragile histidine triad
تعداد نتایج: 35876 فیلتر نتایج به سال:
The Fra3B locus on chromosome 3p14.2 targeting the fragile histidine triad (Fhit) gene represents one of the most common fragile sites of the human genome and is associated with early preneoplastic and malignant disorders in multiple human tumors. Fhit was classified as a tumor suppressor; however, the molecular mechanisms of its function are not well established. Here, we report that Fhit asso...
the FHIT (Fragile Histidine Triad) gene product appeared as a very intriguing molecule to be investigated in the pathogenesis of cancer. In fact, FHIT encompasses the most common fragile site in human [2], whose genetic alterations, leading to the loss of FHIT expression, have been reported in the majority of human cancers [3]. Other than genetic lesions, FHIT expression in both solid and hemat...
In the photosynthetic photosystem II, electrons are transferred from the manganese-containing oxygen evolving complex (OEC) to the oxidized primary electron-donor chlorophyll P680(•+) by a proton-coupled electron transfer process involving a tyrosine-histidine pair. Proton transfer from the tyrosine phenolic group to a histidine nitrogen positions the redox potential of the tyrosine between tho...
Many studies have established that loss of heterozygosity and/or altered expression of the fragile histidine triad (FHIT) gene is a common event in a number of tumor types including prostate carcinoma. Encompassing the most active fragile site in the human genome, FRA3B, FHIT has become the model fragile site-associated tumor suppressor gene. In a recent study, linkage and association between g...
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