نتایج جستجو برای: fractional flow reserve
تعداد نتایج: 563105 فیلتر نتایج به سال:
INTRODUCTION Nicorandil has vasodilatory effects on both the epicardial coronary arteries and the coronary microvasculature, thereby increasing coronary blood flow. Intravenous administration of nicorandil can be applicable for fractional flow reserve (FFR) measurement as a hyperaemic agent and a possible alternative to adenosine. However, the effectiveness of intravenous nicorandil infusion fo...
P hysiologists and physicians have long been interested in blood flow and pressure (i.e., hemodynamics). The importance of the circulatory system in regulating health and disease has been appreciated since the days of blood-letting and leaches. In 1738, Daniel Bernoulli (1) elegantly described the impact of narrowings on pressure and flow in his book Hydrodynamica. The principles he described t...
oronary angiography presently remains the main method for the diagnosis and instruction of epicardial coronary disease. However, precise characterization of the significance for any given stenosis is limited by the inability to identify intermediate coronary lesions responsible for ischemia. In clinical practice, in addition to the assessment of the anatomical details of vessel narrowing, a mor...
In deriving clinically used hemodynamic indices such as fractional flow reserve and coronary flow velocity reserve, simplified models of the coronary circulation are used. In particular, myocardial resistance is assumed to be independent of factors such as heart contraction and driving pressure. These simplifying assumptions are not always justified. In this review we focus on distensibility of...
Fractional flow reserve (FFR) has been recognized as an effective tool to determine functional significance in intermediate coronary lesions and FFR-guided percutaneous coronary intervention (PCI) improves clinical outcomes. However, hemodynamic interaction between serial stenoses within one coronary artery complicates the assessment of functional severity of each individual lesion. We present ...
Effect of High (200 lg/kg per Minute) Adenosine Dose Infusion on Fractional Flow Reserve Variability
Methods and Results-—In a prospective, single-arm study, out of 95 prospectively screened patients, 38 (40.0%) exhibited significant (≥0.05 difference of max Pd/Pa minus min Pd/Pa) variations in Pd/Pa from 15 s post Pd/Pa dip and until the end of a 3-minute adenosine (140 lg/kg per minute) infusion. Thirty patients agreed to participate in a post 5-minute repeat fractional flow reserve assessme...
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