F-box proteins are the substrate-recognition components of the Skp1-Cul1-F box protein (SCF) E3 ubiquitin ligases. Here we report a structural relationship between Fbxo7, a component of the SCF(Fbxo7) E3 ligase, and the proteasome inhibitor PI31. SCF(Fbxo7) is known to catalyze the ubiquitination of hepatoma-up-regulated protein (HURP) and the inhibitor of apoptosis (IAP) protein but also funct...

Demographic and Health Survey (DHS) data could potentially inform optimal strategies to reach women having unmet need with contraceptive services through integrated service delivery. Using 2010-11 DHS data from Nepal, Senegal, and Uganda, we estimate the proportion of married or cohabitating women of reproductive age (MWRA) having unmet need for family planning (FP) who have accessed selected h...

There are little independent data available about how well single nucleotide polymorphism (SNP) genotyping technologies perform in the typical molecular genetics laboratory. We evaluated the utility and accuracy of a widely used technology, template-directed dye-terminator incorporation with fluorescence-polarization detection (FP-TDI), in a sample of 177 SNPs selected solely on the basis of ma...

BACKGROUND The private medical care sector is expanding in urban cities in Sub-Saharan Africa (SSA). However, people's health-care-seeking behaviors in this new landscape remain poorly understood; furthermore, distinguishing between public and private providers and among various types of private providers is critical in this investigation. This study assessed, by type, the healthcare providers ...

We investigate the topological entropy of a green interval map. Defining the complexity we estimate from above the topological entropy of a green interval map with a given complexity. The main result of the paper — stated in Theorem 0.2 — should be regarded as a completion of results of [4]. 0. Introduction and main result The purpose of this paper is to evaluate the topological entropy of gree...

One of the critical problems of Internet GIS is latency time of displaying the map requested by clients due to network traffic. To enhance the user's response time, it is required to minimize the number of interactions between a client and a server. The minimization of network traffic can be achieved by data caching and object prefetching. For Internet GIS applications, the operators we conside...

In the study, an automated visualization of proximity between workers and equipment is developed to manage workers’ safety at construction sites using convolutional-neural-network-based image processing a closed-circuit television video. The images are analyzed automatically transform hazard index visualized in form plane map. graphical representation personalized map proposed termed as ellipse...