There is evidence that local peripheral administration of gabapentin produces antinociception through the activation of the ATP-sensitive K+-channel. However, this interaction has not been evaluated systemically, nor in diabetic rat. This work was undertaken to determine whether glibenclamide has any effect on the systemic antinociception induced by gabapentin. Inflammatory pain was induced by ...

Introduction: Formalin injection induces nociceptive bahaviour in phase I and II, with a quiescent phase between them. While active inhibitory mechanisms are proposed to be responsible for initiation of interphase, the exact mechanisms which lead to termination of nociceptive response in phase II are not clear yet. Phase II is a consequence of peripheral and central sensitization processes, whi...

BACKGROUND Pethidine, an opioid analgesic is used for pain management. Clomipramine a tricyclic antidepressant primarily used for mood management is also used to treat pain. The objective of this study was to investigate the potentiation of the analgesic effects of sub-threshold dose of pethidine by a tricyclic antidepressant, clomipramine. METHODS The antinociceptive activities of clomiprami...

Formalin merupakan bahan kimia yang digunakan sebagai pengawet dalam makanan. Bahan ini bersifat karsinogenik, akumulasi tinggi tubuh akan menyebabkan iritasi lambung, alergi sampai terjadinya kanker saluran cerna. Jenis makanan di pasar diantaranya ayam potong, ikan basah, cumi, kerang, sotong, udang, asin, otak-otak, bakso dan mi basah dengan sengaja menggunakan formalin pengawet. Tujuan peng...

BACKGROUND The combination of two analgesic agents offers advantages in pain treatment. Codeine and morphine analgesia is due to activation of opioid receptor subtypes. METHODS This study, performed in mice using isobolographic analysis, evaluated the type of interaction in intraperitoneal (ip) or intrathecal (it) coadministration of codeine and morphine, in three nociceptive behavioral model...

Phencyclidine (1-(1-phenylcyclohexyl) piperidine, PCP, I) and ketamine (2-O-chlorophenyl-2-methylaminocyclohexan, II) have shown analgesic effects. Some of its derivatives were synthesized and their biological properties have been studied. In this study, a new derivative of PCP, (1-[1-(3-methoxyphenyl) (tetralyl)] piperidine, PCP-OCH3-tetralyl, III) was synthesized and the acute thermal pain of...

sex hormone is supposed to modify pain sensitivity. the aim of the present study was to investigat, the role of 2 adrenergic receptors in nociception using formalin test. formalin test was performed by subcutaneous injection of 50 ml formalin (%2.5) solution into hind paw. animals were divided into 4 groups as control group (intact animal), sham group (received 2µl of artificial csf by icv rout...

in this study, the effects of acute and chronic lithium on nociception induced by formalin and its interactions with morphine-induced analgesia were studied in mice. formalin test was selected to study nociception. subcutaneous injection of different doses of morphine (1.5, 3 and 6 mg/kg) induced analgesia in a dose dependent manner in both phases of the formalin test. intraperitoneal administr...