One of the most significant issues in pharmaceutical industries, prior to commercialization of a pharmaceutical preparation is the "preformulation" stage. However, far too attention has been paid to verification of the software assisted statistical designs in preformulation studies. The main aim of this study was to report a step by step preformulation approach for a semisolid preparation based...

The ingestion of exogenous carbohydrates (CHO) during prolonged endurance exercise, such as long-distance triathlon, is considered beneficial with regard to performance. However, little is known about whether this performance benefit differs among different forms of CHO administration. To this end, the purpose of our study was to determine the impact of CHO ingestion from a semisolid source (GE...

Multichannel intraluminal impedance (MII) is a new technique for evaluation of bolus transport. We evaluated esophageal function using bolus transport time (BTT) and contraction wave velocity (CWV) of liquid, semisolid, and solid boluses. Ten healthy subjects underwent MII swallow evaluation with various boluses of sterile water (pH 5), applesauce, three different sized marshmallows, and iced a...

Following transformation with recombinant plasmid clones, E. coli BL21(DE3) often produced extremely opaque colonies on a standard semisolid agar plate, as compared with the translucent colonies produced by normal, untransformed bacteria A standard BL21(DE3) culture consisted of two kinds of cells one kind produced translucent colonies and the other produced opaque colonies upon transformation ...

A semisolid brucella medium with 10% sheep blood was used for storage and transport of Campylobacter fetus subsp. jejuni and subsp. intestinalis and kept isolated alive about 3 weeks or longer at 25 degrees C or when sent through the regular mail.

Many methods have been proposed for the isolation of temporarily suppressed phases of diphasic Salmonella (Craigie, 1931; Gard, 1938; Hajna, 1944). These absorption methods are effective but require incubation for at least two days and considerable manual labor. Juenker (1946) suggested a procedure by which broth was inoculated with the organisms of the desired phase by passing them through a s...

[Purpose] This study investigated the effect of a combined method incorporating the Mendelsohn maneuver and effortful swallowing on aspiration in patients with dysphagia after stroke. [Subjects and Methods] Three patients with dysphagia were recruited. All patients were treated with a combined method consisting of the Mendelsohn maneuver and effortful swallowing. The intervention period was tot...

Face alignment is an active topic in computer vision, consisting in aligning a shape model on the face. To this end, most modern approaches refine the shape in a cascaded manner, starting from an initial guess. Those shape updates can either be applied in the feature point space (i.e. explicit updates) or in a low-dimensional, parametric space. In this paper, we propose a semi-parametric cascad...

Preliminary experiments revealed that coagulase positive staphylococci could be distinguished culturallv from coagulase negative staphylococci in a soft agar medium containing a small amount of normal human or rabbit plasma. In a medium of suitably low viscosity, staphylococci produce elongated diffuse feathery colonies. When coagulable plasma is incorporated in such a medium, the colonies of c...

Foreign body aspiration occurs when a solid or semisolid object becomes lodged in the larynx or trachea. It can be a life-threatening emergency, especially if it is large enough to occlude the airway. However, small aspirated objects may go unnoticed until symptoms occur. Therefore, it is frequently misdiagnosed. A high level of clinical suspicion, patient's risk factors, and thorough history a...