The incidence of IgE-mediated food allergy (FA) has continued to increase over the years which places substantial burden on patient health and quality life. With no cure for this disease, mainstay management been allergen avoidance. However, there have advancements in FA treatment recent with multiple clinical trials utilizing novel innovative therapeutic strategies. A landmark event came 2020 ...

the principle of cancer immunotherapy includes various methods of manipulations to influence immune responses against tumors in both humans and animals. this advanced technology of hybridoma production provided the necessary skills to efficiently produce highly specific monoclonal antibodies (mab). radioactively-tagged antibodies which are applied in radioimmunotherapy (rit), can target adjacen...

Background One of the most promising therapies in persistent and severe food allergy is oral immunotherapy (OIT), with immediate goal of desensitization and long-term goal of tolerance. However, a subgroup of patients may experience severe allergic reactions. These concerns might be addressed by combination of OIT with another promising therapy involving anti-IgE monoclonal antibodies (omalizum...

Background In natural history of allergy, in some patients sensitized to aeroallergens, appear allergy to novel allergens, and in some cases this are food allergens. Subcutaneous immunotherapy (SIT) is the method of treatment patient with pollen allergy, and one of the aim of this treatment is protection against development novel allergy, but sometimes in clinical practice we observed hypersens...

Rationale CD103+ DCs (dendritic cells) and CCR9+ pDCs (plasmacytoid DCs) have been implicated in promoting tolerance to antigens through regulatory-T cell induction. We have conducted food oral immunotherapy (OIT) clinical studies for the last 3 years at Stanford University. We hypothesized that subjects with food allergies have low CD103+ and CCR9+ expression on their DCs but that these DC pop...

Background Food allergies are a problematic health concern in many developed countries. Oral immunotherapy (OIT) is one of the most promising therapeutic approaches for treating food allergy. The treatment with heated ovomucoidreduced egg white (OM ̅) is especially notable and its effectiveness as OIT in egg allergic patients has been reported: 24 (44%) egg allergic patients became tolerant afte...

Background Prevalence of severe food allergy with high risk of anaphylaxis has been increasing and daily restricted diet and fear of accidental anaphylaxis are great burden on the patients. Oral immunotherapy (OIT) may be a hope for the cure but has not been established at present. We performed OIT for severe food allergy with a unique protocol aiming to achieve the dosing of high amount during...

Background: Asthma is a chronic inflammatory disease characterized by increased infiltration of various inflammatory cells into airway. Several previous studies showed specific immunotherapy improved clinical features of asthma due to aeroallergens. Objective: To describe the efficacy of house dust immunotherapy in childhood asthma with house dust allergy. Methods: The asthmatic patients were c...

Background Food allergy may be life-threatening and affected individuals have impairment in quality of life. Children with multiple and severe food allergies usually have other allergic manifestations like allergy to furry animals and pollen, causing eczema and asthma. Treatment with the anti-IgE (omalizumab) is indicated for severe allergic asthma. Oral immunotherapy (OIT) has been performed i...

Background Coexistence of food hypersensitivity are frequently observed in patients with allergy to plant and animals. Principal method of cure of aeroallergens hypersensitivity is specific allergy immunotherapy (SIT). Effectiveness of this therapy is assessed based on clinical symptoms abated. Sometimes we observed less effect this method of treatment in some patients, probably connected with ...