The folate receptor (FR) is expressed in many tumor types, among those ovarian and lung cancer. Due to the high FR affinity of folic acid, it has been used for targeting of FR-positive tumors, allowing specific delivery of attached probes to the malignant tissue. Therefore, nuclear imaging of FR-positive cancer is of clinical interest for selecting patients who could benefit from innovative the...

INTRODUCTION Detection of (subclinical) synovitis is relevant for both early diagnosis and monitoring of therapy of rheumatoid arthritis (RA). Previously, the potential of imaging (sub)clinical arthritis was demonstrated by targeting the translocator protein in activated macrophages using (R)-[11C]PK11195 and positron emission tomography (PET). Images, however, also showed significant peri-arti...

BACKGROUND The purpose of this study was to develop intraperitoneal hyperthermic therapy based on magnetic fluid hyperthermia, nanoparticle-wrapped cisplatin chemotherapy, and magnetic particles of albumin. In addition, to combine the multiple-killing effects of hyperthermal targeting therapy, chemotherapy, and radiotherapy, the albumin-nanoparticle surfaces were linked with radionuclide (188)R...

A. Specific Aims The original grant proposal contained two specific aims. These aims remain unchanged at this point in the program. The overarching goals of the program relate to the development of multi-responsive/functional hydrogel nanoparticles for cancer cell targeting. This is to be accomplished in the following specific aims: Aim 1: To utilize doxorubicin-loaded, folate-modified, degrada...

Research demonstrated that folate deficiency in either the mother or father could impact biological functions of offspring’s neural cells. Folate can also impair methionine cycle, thus contributing to conversion S-adenosylmethionine (SAM) S-adenosylhomocysteine (SAH), which potentially cause damage central nervous system. The study focused on effect parental cell apoptosis offspring neonatal ra...

FOLATE IS AN ESSENTIAL MICRONUTRIENT that functions as a coenzyme in DNA and RNA synthesis and in the metabolism of several amino acids, including homocysteine (11). Folate deficiency can occur in humans because of poor dietary intake, malabsorption, metabolic blocks, or increased requirements as seen during pregnancy and lactation (3). Symptoms of deficiency are severe and include megoblastic ...