Fluvoxamine CR has been reported effective in the short-term (12-wk) treatment of generalized social anxiety disorder (social phobia). Social anxiety disorder (SAD) is, however, a chronic disorder thought to require maintenance treatment. We report on data from the extension phase of a short-term study, in order to explore the efficacy and safety profile of fluvoxamine CR (100-300 mg/d) in the ...

Zolpidem is widely prescribed in clinical practice for the treatment of sleep disorders and it is generally considered safe and well tolerated. However, several cases of hallucinations, amnesia, and delirium associated with the use of zolpidem have been reported previously (Ansseau et al., 1992; Katz, 1995; Toner et al., 2000). We present an elderly woman who experienced visual hallucinations a...

Background. Ropivacaine, a long-acting, enantiomerically pure amide-type local anesthetic, undergoes extensive hepatic metabolism in humans, with about 1% of an intravenous dose excreted unchanged in the urine. It is metabolized to 3-OHropivacaine by CYP1A2, and to PPX by CYP3A4. The aims of the present studies were to investigate (1) the effects of inhibition (with fluvoxamine, ciprofloxacin, ...

The review is devoted for the solid phase extraction and the extractive spectrophotometric methods for the determination of some psychotropic drugs, e.g. phenothiazines, thioxanthenes, dibenzothiazines, fluoxetine, fluvoxamine, trazodone.

Fluvoxamine (FVX) can be reduced at a mercury-drop electrode, with a maximum peak current intensity being obtained at a potential of -0.7 V vs. Ag/AgCl, in an aqueous electrolyte solution of pH 2. The compound was determined in a pharmaceutical product and in spiked human serum by square-wave adsorptive-stripping voltammetry (SWAdSV) after accumulation at the electrode surface, under batch cond...