نتایج جستجو برای: fluvastatin

تعداد نتایج: 698  

Journal: :The Journal of pharmacology and experimental therapeutics 2007
Antonella Liantonio Viviana Giannuzzi Valentina Cippone Giulia Maria Camerino Sabata Pierno Diana Conte Camerino

The mechanism by which the 3-hydroxy-3-methyl-glutaryl-CoA reductase inhibitors (statins) induce skeletal muscle injury is still under debate. By using fura-2 cytofluorimetry on intact extensor digitorum longus muscle fibers, here we provided the first evidence that 2 months in vivo chronic treatment of rats with fluvastatin (5 and 20 mg kg-1) and atorvastatin (5 and 10 mg kg-1) caused an alter...

Journal: :Gynecologic oncology 2010
Daniel R Scoles Xuan Xu Haimei Wang Hang Tran Barbie Taylor-Harding Andrew Li Beth Y Karlan

OBJECTIVES We previously observed an association between ovarian cancer outcome and statin use and hypothesized lipoproteins have direct effects on ovarian cancer proliferation. Here we investigate the direct effects of low density lipoprotein (LDL) and oxidized LDL (oxLDL) on proliferation and the inhibitory effects of fluvastatin and a liver X receptor (LXR) agonist. METHODS The effects of ...

Journal: :Circulation 1999
C M Ballantyne J A Herd L L Ferlic J K Dunn J A Farmer P H Jones J R Schein A M Gotto

BACKGROUND--Patients with coronary artery disease (CAD) commonly have low HDL cholesterol (HDL-C) and mildly elevated LDL cholesterol (LDL-C), leading to uncertainty as to whether the appropriate goal of therapy should be lowering LDL-C or raising HDL-C. METHODS AND RESULTS--Patients in the Lipoprotein and Coronary Atherosclerosis Study (LCAS) had mildly to moderately elevated LDL-C; many also ...

2010
Petr Ostadal David Alan Jiri Vejvoda Jiri Kukacka Milan Macek Petr Hajek Martin Mates Milan Kvapil Jiri Kettner Martin Wiendl Ondrej Aschermann Josef Slaby Frantisek Holm Peter Telekes David Horak Peter Blasko David Zemanek Josef Veselka Jana Cepova

BACKGROUND Statins have been proved to be effective in reduction of mortality and morbidity when started in the early secondary prevention in stabilized patients after acute coronary syndrome (ACS). The safety and efficacy of statin administration directly in the first-line therapy in unstable ACS patients is not clear. The aim of our study was, therefore, to assess the effect of statin treatme...

2011
Stéphane Jouneau Mélanie Bonizec Chantal Belleguic Benoit Desrues Graziella Brinchault Jeanne Galaine Jean-Pierre Gangneux Corinne Martin-Chouly

BACKGROUND Early in life, patients with cystic fibrosis (CF) are infected with microorganisms including bacteria and fungi, particularly Pseudomonas aeruginosa and Aspergillus fumigatus. Since recent research has identified the anti-inflammatory properties of statins (besides their lipid-lowering effects), we investigated the effect of fluvastatin on the production of the potent neutrophil chem...

Journal: :Fukushima journal of medical science 2011
Mituhiro Gotoh Kenji Mizuno Yoshiaki Ono Michihiko Takahashi

Although several studies have reported a lower risk of osteoporotic fracture in hypercholesterolemic patients (WHO IIa) treated with statin, longitudinal studies on the effects of statins on bone are lacking. The aim of the present study was to evaluate bone mineral density (BMD) and bone turnover changes induced by 3-year fluvastatin treatment in postmenopausal women. Twenty-eight consecutive ...

2016
Yao-Yao Zhou Gui-Qi Zhu Yue Wang Ji-Na Zheng Lu-Yi Ruan Zhang Cheng Bin Hu Shen-Wen Fu Ming-Hua Zheng

OBJECTIVES Usage of statins is suggested to decrease the incidence of HCC. When it comes to different statin subtypes, the chemopreventive action remains controversial. We aim to compare the usage of different statins and reduction of HCC risk. METHODS We searched PubMed, Embase.com and Cochrane Library database up to August 10, 2015. Duplicated or overlapping reports were eliminated. We perf...

Journal: :American journal of physiology. Heart and circulatory physiology 2005
Hiroaki Nishimatsu Etsu Suzuki Hiroshi Satonaka Ryo Takeda Masao Omata Toshiro Fujita Ryozo Nagai Tadaichi Kitamura Yasunobu Hirata

To study the mechanisms of vascular dysfunction in diabetes mellitus, we examined the responses of the aorta to adrenomedullin (AM) and ANG II in obese Zucker (OZ), lean Zucker (LZ), and OZ rats administered fluvastatin (OZ + Flu). AM-induced endothelium-dependent vasorelaxation was impaired in OZ rats compared with LZ rats, and fluvastatin restored AM-induced, endothelium-dependent vasorelaxat...

Journal: :Resuscitation 2007
Chung-Hua Chen Ru-Ping Lee Wen-Tien Wu Kuang-Wen Liao Nanly Hsu Bang-Gee Hsu

OBJECTIVES Sepsis is a severe inflammatory disorder that may lead to multiple organ failure. Lipopolysaccharide (LPS) is associated with Gram-negative sepsis and can activate monocytes and macrophages to release pro-inflammatory mediators such as tumor necrosis factor-alpha (TNF-alpha), nitric oxide (NO) and anti-inflammatory mediator such as interleukin-10 (IL-10). In this present study, we us...

2008
Arini Setiawati Iwan Darmansjah

Fluvastatin XL 80 mg tablet has been marketed in Indonesia since December 2002. This post-marketing surveillance (PMS) was conducted between May 2004 and April 2005 involving 98 general physicians to observe the safety and tolerability of fluvastatin XL 80 mg once daily at bedtime for 8 weeks in the treatment of outpatients with hypercholesterolemia. The efficacy of the drug in lowering LDLchol...

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