The selective serotonin reuptake inhibitor fluoxetine significantly enhances adult visual cortex plasticity within the rat. This effect is related to decreased gamma-aminobutyric acid (GABA) mediated inhibition and identifies fluoxetine as a potential agent for enhancing plasticity in the adult human brain. We tested the hypothesis that fluoxetine would enhance visual perceptual learning of a m...

Objectives: The objective was to evaluate the seizure provoking effect of sumatriptan, and its abolition with fluoxetine in the pentylenetetrazolinduced seizures in rats. Methods: 100 Sprague-Dawley rats of either sex were randomized into 10 groups with each group consisting 10 rats. The first group was taken as a control group which received distilled water. The second group and the third grou...

After spinal cord injury, the disruption of blood-spinal cord barrier by activation of matrix metalloprotease is a critical event leading to infiltration of blood cells, inflammatory responses and neuronal cell death, contributing to permanent neurological disability. Recent evidence indicates that fluoxetine, an anti-depressant drug, is shown to have neuroprotective effects in ischaemic brain ...

In mice, disseminated coagulation, inflammation, and ischemia induce neurological damage that can lead to death. These symptoms result from circulating bubbles generated by a pathogenic decompression. Acute fluoxetine treatment or the presence of the TREK-1 potassium channel increases the survival rate when mice are subjected to an experimental dive/decompression protocol. This is a paradox bec...

Selective serotonin reuptake inhibitors can lead to increased prolactin levels and galactorrhea. Herein, we reported a 40-year-old female patient who developed galactorrhea hyperprolactinemia two weeks after initiation of fluoxetine 20 mg/day. Galactorrhea was discontinued the fifth week withdrawal reached normal limits. The patient's depressive symptoms disappeared with citalopram 40 mg/day no...

This paper explores the use of nanofiltration (NF) and Reverse Osmosis (RO) to remove pharmaceutical Fluoxetine (FLX) from water. substance can be found in rivers lakes requires studies involving application efficient technologies for its removal or mitigation. The study evaluated NF RO membranes as an alternative removed fluoxetine within range between 50 60%, demonstrated higher efficiency re...

Recently, many cases of Fluoxetine induced mania have been reported in the literature. The detailed analysis of these case reports demonstrates that these patients had either positive family history of affective disorder (Lebegne, 1987), past history of affective illness (Settle and Settle, 1984; Lebegne, 1987; Nakra el al., 1989) or were related to high doses of fluoxetine (Chouinard and Stein...

Methamphetamine (MA) abuse is a major public health and safety concern throughout the world and a growing burden on healthcare costs. The purpose of the present study was to investigate the protective effect of fluoxetine against MA‑induced chronic pulmonary inflammation and to evaluate the potential role of nuclear factor erythroid 2-related factor 2 (Nrf2)-mediated antioxidative stress. Wista...