نتایج جستجو برای: flt3 itd
تعداد نتایج: 4119 فیلتر نتایج به سال:
چکید ه سابقه و هدف NPM1 / نوکلئوفسمین/ B23 ، یک فسفوپروتئین با میزان بیان بالا در سلول‌های در حال تکثیر است. بیماران AML با NPM1 به شکل شایعی دارای جهش‌های FLT3 ITD می‌باشند. هدف این تحقیق بررسی میزان فراوانی جهش‌های NPM1 و FLT3 ITD در بیماران AML ایرانی و ارتباط این جهش‌ها با زیر گروه‌های AML در طبقه‌بندی FAB بود. مواد و روش‌ها مطالعه انجام شده از نوع توصیفی مقطعی بود. نمونه‌های مغز ...
FLT3 internal tandem duplication (ITD), one of the most frequent mutations in Acute Myeloid Leukemia (AML), is reported to be an unstable marker, as it can evolve from FLT3 ITD- to ITD+ during the disease course. A single-gene sensitive mutational screening approach may be helpful for better clarifying the exact timing of mutation occurrence, especially when FLT3 ITD appears to occur late, at d...
Risk associated to FLT3 internal tandem duplication (FLT3-ITD) in patients with acute myeloid leukemia (AML) may depend on mutational burden and its interaction with other mutations. We analyzed the effect of FLT3-ITD/FLT3 wild-type (FLT3wt) ratio depending on NPM1 mutation (NPM1mut) in 303 patients with intermediate-risk cytogenetics AML treated with intensive chemotherapy. Among NPM1mut patie...
FLT3 mutations are common genetic changes, and are reported to have prognostic significance in acute myeloid leukemia (AML). The FLT3 internal tandem duplication (ITD) and the D835 activating mutation in the tyrosine kinase domain (TKD) were analyzed by polymerase chain reaction (PCR) in the genomic DNA of Korean patients with AML at diagnosis and during follow-up. There were 226 patients with ...
background: the secondary genetic changes other than the promyelocytic leukemia-retinoic acid receptor (pml-rara) fusion gene may contribute to the acute promyelocytic leukemogenesis. chromosomal alterations and mutation of flt3 (fms-like tyrosine kinase 3) tyrosine kinase receptor are the frequent genetic alterations in acute myeloid leukemia. however, the prognostic significance of flt3 mutat...
سابقه و هدف: جهش ژن flt3 (گیرنده تیروزین کینازی شبه) FMS باعث تکثیر بدون کنترل سلول های لوسمیک شده و پیش آگهی بدی را به همراه دارد. هدف ما از این مطالعه اجرایی کردن آزمایشات مولکولی برای تشخیص و غربالگری این جهش ها در مبتلایان لوسمی های حاد بود.روش بررسی: در این مطالعه بنیادی، 91 کودک مبتلا به لوسمی های حاد میلوئیدی (AML) و لنفوئیدی (ALL) از نظر جهش در ژن flt3 شامل وجود جهش ITD (Internal Tandem...
FLT3 is frequently mutated in acute myeloid leukemia (AML), but resistance has limited the benefit of tyrosine kinase inhibitors (TKI). We demonstrate that statins can impair FLT3 glycosylation, thus leading to loss of surface expression and induction of cell death, as well as mitigation of TKI resistance. Immunofluorescence microscopy confirms a reduction in surface localization and an increas...
The presence of internal tandem duplications (ITD) in the Fms-related tyrosine kinase 3 receptor (FLT3) has been associated with a poor prognosis in acute myeloid leukemia (AML). Over the past decade, FLT3 is a promising target in FLT3-ITD-positive AML. Sorafenib which is one of the commonly focused FLT3 inhibitors may improve outcome, but only few patients display long-term responses in previo...
AIM To assess the expression level of fms-like tyrosine kinase 3 (FLT3), the incidence of FLT3/internal tandem duplications (ITD) mutation, and prognostic value of FLT3 changes in different types of adult leukemia. METHODS Bone marrow mononuclear cells were isolated from 147 adult patients with leukemia. Reverse transcriptase polymerase chain reaction (PCR) was used to screen FLT3/ITD mutatio...
Spontaneous remission (SR) of acute myeloid leukemia (AML) is a very rare phenomenon. AML characterized by FLT3 internal tandem duplication (FLT3 ITD) is typically associated with an aggressive clinical course with rapid progression, relapse, and short overall survival in the absence of transplantation. We report here the first case of SR of FLT3 ITD mutant AML in the literature. Our patient wa...
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