نتایج جستجو برای: flt pet

تعداد نتایج: 55040  

Journal: :Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2008
Michelle S Bradbury Dolores Hambardzumyan Pat B Zanzonico Jazmin Schwartz Shangde Cai Eva M Burnazi Valerie Longo Steven M Larson Eric C Holland

UNLABELLED 3'-Deoxy-3'-(18)F-fluorothymidine ((18)F-FLT), a partially metabolized thymidine analog, has been used in preclinical and clinical settings for the diagnostic evaluation and therapeutic monitoring of tumor proliferation status. We investigated the use of (18)F-FLT for detecting and characterizing genetically engineered mouse (GEM) high-grade gliomas and evaluating the pharmacokinetic...

Journal: :Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2013
Omid S Tehrani Anthony F Shields

Several new tracers are being developed for use with PET to assess pathways that are altered in cancers, including energy use, cellular signaling, transport, and proliferation. Because increased proliferation is a hallmark of many cancers, several tracers have been tested to track the DNA synthesis pathway. Thymidine, which is incorporated into DNA but not RNA, has been used in laboratory studi...

2013
Matthias Scheffler Thomas Zander Lucia Nogova Carsten Kobe Deniz Kahraman Markus Dietlein Irini Papachristou Lukas Heukamp Reinhard Büttner Ron Boellaard Adriaan A. Lammertsma Silvia Querings Erich Stoelben Walburga Engel-Riedel Bernd Neumaier Jürgen Wolf

UNLABELLED 3'-deoxy-3'-[(18)F]fluoro-L-thymidine (FLT) and 2'-deoxy-2'-[(18)F]fluoro-D-glucose (FDG) are used to visualize proliferative and metabolic activity of tumors. In this study we aimed at evaluating the prognostic value of FLT and FDG uptake measured by positron emission tomography (PET) in patients with metastatic non-small cell lung cancer (NSCLC) prior to systemic therapy with erlot...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2009
Chirayu Shah Todd W Miller Shelby K Wyatt Eliot T McKinley Maria Graciela Olivares Violeta Sanchez Donald D Nolting Jason R Buck Ping Zhao M Sib Ansari Ronald M Baldwin John C Gore Rachel Schiff Carlos L Arteaga H Charles Manning

PURPOSE To evaluate noninvasive imaging methods as predictive biomarkers of response to trastuzumab in mouse models of HER2-overexpressing breast cancer. The correlation between tumor regression and molecular imaging of apoptosis, glucose metabolism, and cellular proliferation was evaluated longitudinally in responding and nonresponding tumor-bearing cohorts. EXPERIMENTAL DESIGN Mammary tumor...

Journal: :Nuclear medicine review. Central & Eastern Europe 2014
Otakar Belohlavek Pavel Fencl Martin Majovsky Monika Jaruskova Vladimir Benes

BACKGROUND Low-grade gliomas (LGG) of the brain have an uncertain prognosis, as many of them show continuous growth or upgrade over the course of time. We retrospectively investigated the role of positron emission tomography with 3'-deoxy-3'-[18F]fluorothymidine (FLT-PET) in the prediction of overall survival and event free survival in patients with untreated LGG. No such information is yet ava...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2010
Maria Adele Rueger Heiko Backes Maureen Walberer Bernd Neumaier Roland Ullrich Marie-Lune Simard Beata Emig Gereon Rudolf Fink Mathias Hoehn Rudolf Graf Michael Schroeter

Neural stem cells reside in two major niches in the adult brain [i.e., the subventricular zone (SVZ) and the dentate gyrus of the hippocampus]. Insults to the brain such as cerebral ischemia result in a physiological mobilization of endogenous neural stem cells. Since recent studies showed that pharmacological stimulation can be used to expand the endogenous neural stem cell niche, hope has bee...

Journal: :Physics in medicine and biology 2018
Matthew Scarpelli Jens Eickhoff Enrique Cuna Scott Perlman Robert Jeraj

The statistical analysis of positron emission tomography (PET) standardized uptake value (SUV) measurements is challenging due to the skewed nature of SUV distributions. This limits utilization of powerful parametric statistical models for analyzing SUV measurements. An ad-hoc approach, which is frequently used in practice, is to blindly use a log transformation, which may or may not result in ...

2011
Wan-Chi Lee Chih-Hsien Chang Chung-Li Ho Liang-Cheng Chen Yu-Hsien Wu Jenn-Tzong Chen Ying-Ling Wang Te-Wei Lee

Fluorine-18 fluorodeoxyglucose ((18)F-FDG) positron emission tomography (PET) imaging demonstrated the change of glucose consumption of tumor cells, but problems with specificity and difficulties in early detection of tumor response to chemotherapy have led to the development of new PET tracers. Fluorine-18-fluorothymidine ((18)F-FLT) images cellular proliferation by entering the salvage pathwa...

2017
Xiaoli Zhang Jinming Yu Chengming Li Xindong Sun Xue Meng

Accelerated repopulation has been observed in various tumors. This study was aimed to evaluate the potential of 3'-deoxy-3'-18F-fluorothymidine (18F-FLT) uptake and Computed Tomography Number (CTN) in monitoring tumor responses to radiotherapy compared with tumor volume (TV) changes. Tumor bearing nude mice were assigned to either irradiated daily or every second day group and then randomized t...

2014
Francesca Iommelli Viviana De Rosa Sara Gargiulo Mariarosaria Panico Marcello Monti Matteo Gramanzini Giovanni Ortosecco Rosa Fonti Arturo Brunetti Silvana Del Vecchio

Purpose: MET amplification is one of the mechanisms underlying acquired resistance to EGFR tyrosine kinase inhibitors (TKI) in non–small cell lung cancer (NSCLC). Here, we tested whether 30-deoxy-30-[18F]-fluorothymidine ([F]FLT) positron emission tomography/computerized tomography (PET/CT) can detect MET-mediated resistance to EGFR TKIs and monitor the effects of MET inhibitors in NSCLC. Exper...

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