Ophthalmic photography is a system of information transferral. In fundus photography, a visual description of the three-dimensional retinal and choroidal tissues is transferred to film. This twodimensional representation is used by the physician to make judgments concerning the health and treatment of the patient's retina. An accurate representation of the retinal and choroidal tissues is the g...

Background: Surgery and accurate removal of the brain tumor in the operating room and after opening the scalp is one of the major challenges for neurosurgeons due to the removal of skull pressure and displacement and deformation of the brain tissue. This displacement of the brain changes the location of the tumor relative to the MR image taken preoperatively. Methods: This study, which is done...

We present a novel framework for learning a joint shape and appearance model from a large set of un-labelled training examples in arbitrary positions and orientations. The shape and intensity spaces are unified by implicitly representing shapes as “images” in the space of distance transforms. A stochastic chord-based matching algorithm is developed to align photo-realistic training examples und...

BACKGROUND Non-alcoholic fatty liver disease (NAFLD) is defined as a spectrum of conditions ranging from hepatocellular steatosis to steatohepatitis and fibrosis, progressing to cirrhosis, which occur in the absence of excessive alcohol use. Several animal models capture aspects of NAFLD but are limited either in their representation of the disease stages or use for development of therapeutics ...

Freeform deformation techniques are powerful and flexible tools for interactive 3D shape editing. However, while interactivity is the key constraint for the usability of such tools, it cannot be maintained when the complexity of either the 3D model or the applied deformation exceeds a given workstation-dependent threshold. In this system paper, we solve this scalability problem by introducing a...