IMPORTANCE Fibromyalgia is present in as much as 2% to 8% of the population, is characterized by widespread pain, and is often accompanied by fatigue, memory problems, and sleep disturbances. OBJECTIVE To review the epidemiology, pathophysiology, diagnosis, and treatment of fibromyalgia. EVIDENCE REVIEW The medical literature on fibromyalgia was reviewed from 1955 to March 2014 via MEDLINE ...

OBJECTIVE To develop simple, practical criteria for clinical diagnosis of fibromyalgia that are suitable for use in primary and specialty care and that do not require a tender point examination, and to provide a severity scale for characteristic fibromyalgia symptoms. METHODS We performed a multicenter study of 829 previously diagnosed fibromyalgia patients and controls using physician physic...

Fibromyalgia patients are suffering distressing pain-centered symptoms, and therefore the clarification of fibromyalgia pathophysiology and the development of more effective therapeutic options are urgent issues. In the preclinical phase of analgesic drug development, experimental animal pain models have been widely used to investigate analgesic efficacies of candidate agents. In this approach,...

BACKGROUND Fibromyalgia diagnosis is a challenging and long process, especially among primary care physicians (PCPs), because of symptom heterogeneity, co-morbidities and clinical overlap with other disorders. The purpose was to develop and validate a screening tool in French (FR), German (DE) and English (UK) to help PCPs identify patients with fibromyalgia. METHODS The FibroDetect questionn...

OBJECTIVE While psychosocial factors have been associated with poorer outcomes after knee and hip arthroplasty, we hypothesized that augmented pain perception, as occurs in conditions such as fibromyalgia, may account for decreased responsiveness to primary knee and hip arthroplasty. METHODS A prospective, observational cohort study was conducted. Preoperative phenotyping was conducted using ...

Objective. To test the gender differences in tenderness, impact of fibromyalgia, health-related quality of life, fatigue, sleep quality, mental health, cognitive performance, pain-cognition, and positive health in Spanish fibromyalgia patients and in age-matched nonfibromyalgia individuals from the same region. To test the optimal cut-off score of the different tender points for women and men. ...

BACKGROUND Previous qualitative research has revealed that people with fibromyalgia use daytime napping as a coping strategy for managing symptoms against clinical advice. Yet there is no evidence to suggest whether daytime napping is beneficial or detrimental for people with fibromyalgia. The purpose of this study was to explore how people use daytime naps and to determine the links between da...

OBJECTIVE To assess the transcultural equivalency of the Spanish version of the Fibromyalgia Rapid Screening Tool (FiRST) and its discriminatory ability in different Latin American samples. DESIGN Validation study. SETTING Departments of Rheumatology in general hospitals and private centers; fibromyalgia unit in a university hospital. SUBJECTS 350 chronic pain patients from Spain, Argenti...

BACKGROUND We hypothesized that a substantial proportion of the subjectively experienced variance in pain in fibromyalgia patients would be explained by psychological factors alone, but that a combined model, including neuroendocrine and autonomic factors, would give the most parsimonious explanation of variance in pain. METHODS Psychometric assessment included McGill Pain Questionnaire, Gene...

OBJECTIVE The purpose of this study was to identify exercise protocols incorporating isometric contractions that provide pain relief in women with fibromyalgia. DESIGN A before-after trial. SETTING A physical therapy department in an academic setting. PARTICIPANTS Fifteen women (mean ± SD, 52±11y) with fibromyalgia. INTERVENTIONS Subjects completed 4 sessions: 1 familiarization and 3 ex...