*Singh, K; *Masuda, K; *Thonar, E.; *An, H; +*Cs-Szabo, G +* Rush University Medical Center, Chicago, IL [email protected] INTRODUCTION: The functions of the intervertebral disc (IVD) as a unit, and of the annulus fibrosus (AF) and nucleus pulposus (NP) individually, are determined by the molecular composition of their extracellular matrices (ECM). The outerand inner-AF consists of large collag...