نتایج جستجو برای: fibroin

تعداد نتایج: 1737  

Journal: :Nanoscale 2013
Xiang Fei Zhengzhong Shao Xin Chen

Three-dimensional (3D) copper oxide (CuO) nanostructures were synthesized in a regenerated Bombyx mori silk fibroin aqueous solution at room temperature. In the synthesis process, silk fibroin served as the template and helped to form the hierarchical CuO nanostructures by self-assembly. Cu(OH)2 nanowires were formed initially, and then they transformed into almond-like CuO nanostructures with ...

2012
Mitsuru Sato Katsura Kojima Chisato Sakuma Maria Murakami Eriko Aratani Takato Takenouchi Yasushi Tamada Hiroshi Kitani

Bombyx mori (silkworm) silk proteins are being utilized as unique biomaterials for medical applications. Chemical modification or post-conjugation of bioactive ligands expand the applicability of silk proteins; however, the processes are elaborate and costly. In this study, we used transgenic silkworm technology to develop single-chain variable fragment (scFv)-conjugated silk fibroin. The cocoo...

Journal: :Journal of tissue engineering and regenerative medicine 2010
P C Bessa E R Balmayor H S Azevedo S Nürnberger M Casal M van Griensven R L Reis H Redl

Bone morphogenetic proteins (BMPs) are cytokines with strong ability to promote new bone formation. Herein, we report the use of silk fibroin microparticles as carriers for the delivery of BMP-2, BMP-9 or BMP-14. BMP-containing fibroin microparticles were prepared by a mild methodology using dropwise addition of ethanol, exhibiting mean diameters of 2.7 +/- 0.3 microm. Encapsulation efficiencie...

Journal: :Molecular and cellular biology 1986
M Tsuda S Hirose Y Suzuki

The addition of exogenous histones has an inhibitory effect on fibroin gene transcription in posterior silk gland extracts. The histones probably disturb a process in complex formation, because when transcription complexes were constructed by preincubation of the templates with the extracts, the inhibitory effect of histones was greatly reduced. Transcription of a fibroin gene construct, pFb5' ...

2014
Hai-Yan Wang Yu-Qing Zhang

Silk fibroin can be made into various forms of biocompatible medical materials, including hydrogel due to its excellent properties. Here, we report a novel method for the preparation of electropolymerized silk fibroin hydrogel membrane (ESFHM), which is formed on a nanoporous film as a barrier using a homemade device at a higher DC voltage. Regenerated silk fibroin solution in Tris buffer (pH 6...

2017
Chae Eun Kim Ji Hyun Lee Yeung Kyu Yeon Chan Hum Park JaeWook Yang

The study aimed to investigate the effects of silk fibroin in a mouse model of dry eye. The experimental dry eye mouse model was developed using more than twelve-weeks-old NOD.B10.H2b mice exposing them to 30-40% ambient humidity and injecting them with scopolamine hydrobromide for 10 days. Tear production and corneal irregularity score were measured by the instillation of phosphate buffered sa...

Journal: :Tissue engineering. Part C, Methods 2010
Paulo César Bessa Elizabeth R Balmayor Joachim Hartinger Gerald Zanoni Daniela Dopler Alexandra Meinl Asmita Banerjee Margarida Casal Heinz Redl Rui L Reis Martijn van Griensven

The in vitro and in vivo efficiency of fibroin microparticles as a delivery carrier for bone morphogenetic protein-2 (BMP-2) was evaluated. BMP-2 was encapsulated in silk fibroin particles that were produced by a simple and very mild processing method. The dose-response of BMP-2-loaded fibroin particles was examined in C2C12 cells, after 5 days of culture. The BMP-2 retained most of its activit...

2005
M. Mondal Nirmal Kumar

The domesticated silkworm, Bombyx mori Linn., a lepidopteran molecular model and an important economic insect that are emerging as an ideal molecular genetic resource for solving a broad range of biological problems. The silkworm, B. mori produces massive amount of silk proteins during the final stage of larval development. These proteins are stored in the middle silk gland and they are dischar...

Journal: :Advanced Healthcare Materials 2021

Adv. Healthcare Mater. 2021, 10, 2002083 DOI: 10.1002/adhm.202002083 In the published version of this article, word “doped” in misspelled as “dopted” throughout article. This mistake appears Title, Abstract, Introduction, and Conclusion. The correct title is: Highly Stretchable, Adhesive, Self-Healing Silk Fibroin-Doped Hydrogels for Wearable Sensors sentence Abstract Here, a simple one-pot met...

Journal: :Biomacromolecules 2004
Yuhong Yang Zhengzhong Shao Xin Chen Ping Zhou

Fluorescence and circular dichroism spectroscopy were used to monitor the conformational transition of regenerated Bombyx mori silk fibroin (RSF) in aqueous solutions under different conditions. According to the analysis of fluorescence spectra using anilinonaphthalene-8-sulfonic acid magnesium salt (ANS) as an external probe, the destruction of the hydrophobic core prior to the secondary struc...

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