Background: Coastal areas have a high bacterial diversity, which can be used as source of pharmaceutical substances, including the fibrinolytic enzyme. Fibrinolytic enzymes lyse blood clots by degrading fibrin. These are important for treating circulatory disorders, e.g., pulmonary embolism, deep vein thrombosis, and myocardial infarction. Objective: This study aimed to determine activity crude...

The effects of acute fat feeding on fibrinolytic activity, platelet aggregation, and Stypven time in 10 Africans and 10 Asians are presented and compared with the results previously obtained in 10 Europeans. These indicated that the inhibition of fibrinolytic activity seen in Europeans does not occur in either Africans or Asians although the Stypven time was shortened in all three groups. Plate...

In eight patients with cirrhosis of the liver and portal hypertension an intravenous infusion of lysine vasopressin induced a rapid increase in the plasma level of the fibrinolytic proenzyme plasminogen activator. In contrast, triglycyl lysine vasopressin (glypressin; GVP), in a dose known to lower portal venous pressure, produced no fibrinolytic response. This lack of fibrinolytic response rep...

Rice chaff (Variety: Devamallige) is used as the substrate for the production of fibrinolytic enzyme by Penicilliumchrysogenum AGSF16 in solid state fermentation. The optimized moisture content of the medium is 35-45 %( v/w) an inoculumof 5-10% (v/v) and an average particle size of 400μm of the substrate were optimum for productivity and enzyme activity of 65-70 IU per ml filtrate was achieved ...

Diurnal patterns of plasma euglobulin fibrinolytic activity, estimated by the fibrin plate method, were determined in groups of young normal and older normal subjects, in subjects with type IV hyperlipoproteinemia, and in subjects with coronary artery disease who had normal lipid profiles. The marked diumal increases in fibrinolytic activity observed in the young normal subjects were significan...

A double blind, crossover study of fibrinolytic enhancement treatment using stanozolol has been performed in primary Raynaud's phenomenon and in systemic sclerosis. The outcome criteria included subjective evaluation, clinical examination, physiological measurements of peripheral blood flow, and fibrinolytic measurements. Nineteen patients entered and 11 completed the study of primary Raynaud's...

Fibrinolytic enzymes have wide applications in clinical and waste treatment. Bacterial isolates were screened for fibrinolytic enzyme producing ability by skimmed milk agar plate using bromocresol green dye, fibrin plate method, zymography analysis, and goat blood clot lysis. After these sequential screenings, Bacillus sp. IND12 was selected for fibrinolytic enzyme production. Bacillus sp. IND1...

BACKGROUND & OBJECTIVE Treatment of thromboembolic vascular disease has relied on anticoagulants. However, recognition that lysis of preformed fibrin could be accomplished in vivo by a process involving the conversion of inactive plasminogen to active plasmin enzyme led to an alternative enzyme-based approach. The drugs used for this therapy are called the fibrinolytic enzymes. In this study we...

This book describes the fibrinolytic enzymes of microbial origin that are able to dissolve endogenous thrombi in vivo. The fibrinolytic enzyme streptokinase for example, is produced by b-hemolytic streptococci and exerts its enzyme action indirectly by activating plasminogen. On the other hand, staphylokinase is produced by Staphylococcus aureus by stoichiometric complexation with plasmin(ogen)...

Early graft occlusion is a common complication in patients undergoing aorto-coronary bypass surgery. Both mechanical and haemostatic factors play a role in the pathogenesis of thrombotic occlusion. Several studies have demonstrated a relationship between fibrinolytic activity and venous or arterial thrombosis. We undertook this study to evaluate the possible contribution of the fibrinolytic sys...