Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide. To investigate effect silymarin on chronic (COPD). The serum samples 20 healthy controls, patients with acute exacerbation COPD and stable were collected. LPS smoking used to induce mouse model. Our results showed that in COPD, O2-level release from peripheral blood neutrophils negatively correlated forc...

The effects of electronic-cigarette use (vaping), marketed as a healthier alternative to cigarette smoking (CS), on lung function remain equivocal. Therefore, this study assessed and compared the vaping CS maximum respiratory pressures (MRP), carboxyhaemoglobin levels. Forty-four young healthy participants were recruited: vapers (n = 12), smokers 14), people who had never vaped nor smoked (cont...

Background: Metabolic syndrome is a cluster of cardio- metabolic risk factors characterized by abdominal obesity, insulin resistance, and chronic systemic inflammation. Objectives: i)To assess pulmonary function in people with ii)To whether each component affects indices. Methodology: After detailed history physical examination, subjects underwent investigations like fasting lipid profile, bloo...

IN A CURRENT PAPER in the Journal of Applied Physiology (3) the authors have tried to find out whether the compression of the gas in the lungs during a forced expiration influences the grading of decreased lung function in patients with sick lungs either due to emphysema or chronic bronchitis. They utilize the fact that during a forced expiration FEV1, measured plethysmographically (FEV1-pl) is...

Bronchial hyperresponsiveness to inhaled histamine in smokers is associated with an accelerated annual decline in FEV1 and low baseline FEV1 values. The evolution of bronchial hyperresponsiveness and whether it precedes or follows the accelerated decline in FEV1 and reduction in FEV1 is unknown. Measurements of the provocative concentration of inhaled histamine required to reduce FEV1 by 20% (P...

conclusions the fev1/fev6 ratio can be used as a valid surrogate for fev1/fvc in the diagnosis of airway obstruction, especially for screening purposes in high-risk populations for copd. moreover, fev6 is an acceptable alternative for fvc in detection of restrictive pattern. results this study shows that the current cut-off points used to detect obstruction and restriction can be replaced by fe...

BACKGROUND COPD is defined as partly irreversible airflow obstruction. The response pattern of bronchodilators has not been followed in advanced lung function parameters. PURPOSE The aim of this study was to investigate bronchodilator response pattern in advanced lung function parameters in a continuous fashion along forced expiratory volume in 1 second (FEV1) percent predicted (%p) in COPD p...

BACKGROUND Forced expiratory volume in 6 s (FEV6) and FEV1/FEV6 ratio have traditionally been used as a surrogate for forced vital capacity (FVC) and FEV1/FVC in the assessment of spirometric lung function in nonpregnant subjects. However, the existence of this relationship during pregnancy is yet to be ascertained. AIM The aim of this study was to determine if FEV6 and FEV1/FEV6 can effectiv...

We compared spirometry (FEV1) and airway impedance (z) in the assessment of airway responsiveness to histamine. Airway impedance was measured by the oscillator technique during quiet breathing; both measurements were made twice after each increment of histamine during the challenge. Percentage change in impedance was related to percentage change in FEV1 according to: -delta z = 1.09-2.66 (delta...