The demonstration that information required for the generation of neurons before glia is intrinsic to individual stem cell–derived clones poses the question of mechanism. One possibility is that there is a clock intrinsic to stem cells that determines when daughter cells will be Discussions of CNS stem cell biology often leave the specified to adopt neuronal fates and when they will impression ...

The Mpl receptor plays an important role at the level of adult hematopoietic stem cells, but little is known of its function in embryonic and fetal hematopoiesis. We investigated the signals sent by the MPL cytoplasmic domain in fetal liver hematopoietic progenitors and during embryonic stem (ES) cell hematopoietic commitment. Mpl was found to be expressed only from day 6 of ES cell differentia...

The demonstration that information required for the generation of neurons before glia is intrinsic to individual stem cell–derived clones poses the question of mechanism. One possibility is that there is a clock intrinsic to stem cells that determines when daughter cells will be Discussions of CNS stem cell biology often leave the specified to adopt neuronal fates and when they will impression ...

The demonstration that information required for the generation of neurons before glia is intrinsic to individual stem cell–derived clones poses the question of mechanism. One possibility is that there is a clock intrinsic to stem cells that determines when daughter cells will be Discussions of CNS stem cell biology often leave the specified to adopt neuronal fates and when they will impression ...

The demonstration that information required for the generation of neurons before glia is intrinsic to individual stem cell–derived clones poses the question of mechanism. One possibility is that there is a clock intrinsic to stem cells that determines when daughter cells will be Discussions of CNS stem cell biology often leave the specified to adopt neuronal fates and when they will impression ...

Cardiovascular disease remains the leading cause of morbidity and mortality in the United States and Europe. In recent years, the understanding that regenerative processes exist at the level of the myocardium, has placed stem cell research at center stage in cardiology. A stem cell is a cell that has the ability to divide (self replicate) for indefinite periods often throughout the life of the ...

Ovine parturition is initiated by increases in fetal hypothalamus-pituitary-adrenal (HPA) axis activity, which in turn increase placental estrogen biosynthesis and ultimately increase uterine contractility. In addition to the action in the uterus, estrogens augment fetal ACTH secretion. In late gestation, estrone sulfate is more abundant in fetal plasma than is unconjugated estrone. We studied ...

Human mesenchymal stem cells (hMSCs), which also called mesenchymal stromal cells, are multipotent stem cell. Human MSCs typically are positive for the surface markers CD44, CD73, CD90, CD105, CD106, and also negative for hematopoietic markers CD34 and CD45.These cells can be isolated from postnatal bone marrow, adipose tissue, placenta, and scalp tissue, as well as from various fetal tissues. ...

Fetal stem cells isolated from umbilical cord blood (UCB) possess a great capacity for proliferation and differentiation and serve as a valuable model system to study gene regulation. Expanded knowledge of the molecular control of hemoglobin synthesis will provide a basis for rational design of therapies for β-hemoglobinopathies. Transcriptome data are available for erythroid progenitors derive...

Articles should focus on stem cell biology and may include the following topics: Stem cell properties § § Types, including hematopoietic stem cells, embryonic stem cells, mesenchymal stem cells and induced pluripotent stem cells, plasticity and immunophenotype. Stem cell biology § § Microenvironment niches, including bone marrow and fetal liver, gene regulation including that of transcription f...