نتایج جستجو برای: ferroxidase

تعداد نتایج: 334  

Journal: :research in pharmaceutical sciences 0
sz samsam shariat n alinejad

ceruloplasmin (cp) is a human plasma protein with multiple physiological functions including ferroxidase and oxidase activities. deficiency or inhibition of the enzyme may lead to some abnormalities, including iron deposition in several tissues and causes various pathological conditions in the body. direct interaction of cadmium (cd), a widespread, highly toxic environmental pollutant, with hum...

Journal: :Cell 2010
James A. Duce Andrew Tsatsanis Michael A. Cater Simon A. James Elysia Robb Krutika Wikhe Su Ling Leong Keyla Perez Timothy Johanssen Mark A. Greenough Hyun-Hee Cho Denise Galatis Robert D. Moir Colin L. Masters Catriona McLean Rudolph E. Tanzi Roberto Cappai Kevin J. Barnham Giuseppe D. Ciccotosto Jack T. Rogers Ashley I. Bush

Alzheimer's Disease (AD) is complicated by pro-oxidant intraneuronal Fe(2+) elevation as well as extracellular Zn(2+) accumulation within amyloid plaque. We found that the AD β-amyloid protein precursor (APP) possesses ferroxidase activity mediated by a conserved H-ferritin-like active site, which is inhibited specifically by Zn(2+). Like ceruloplasmin, APP catalytically oxidizes Fe(2+), loads ...

2018
Alan Zanardi Antonio Conti Marco Cremonesi Patrizia D'Adamo Enrica Gilberti Pietro Apostoli Carlo Vittorio Cannistraci Alberto Piperno Samuel David Massimo Alessio

Aceruloplasminemia is a monogenic disease caused by mutations in the ceruloplasmin gene that result in loss of protein ferroxidase activity. Ceruloplasmin plays a role in iron homeostasis, and its activity impairment leads to iron accumulation in liver, pancreas, and brain. Iron deposition promotes diabetes, retinal degeneration, and progressive neurodegeneration. Current therapies mainly based...

Journal: :Biochemical Society transactions 2005
Vadim Vassiliev Zena Leah Harris Paolo Zatta

For decades, abnormalities in ceruloplasmin (Cp) synthesis have been associated with neurodegenerative disease. From the early observation that low circulating serum ceruloplasmin levels served as a marker for Wilson's disease to the recent characterization of a neurodegenerative disorder associated with a complete lack of serum ceruloplasmin, the link between Cp and neuropathology has strength...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2012
Perungavur N Ranganathan Yan Lu Brie K Fuqua James F Collins

Hephaestin (Heph), a membrane-bound multicopper ferroxidase (FOX) expressed in duodenal enterocytes, is required for optimal iron absorption. However, sex-linked anemia (sla) mice harboring a 194-amino acid deletion in the Heph protein are able to absorb dietary iron despite reduced expression and mislocalization of the mutant protein. Thus Heph may not be essential, and mice are able to compen...

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